ID 109763
Title Transcription
シンケイ カンサイボウ ノ セイシツ ト イショクゴ ノ ブンカ ドウタイ ニツイテ
Title Alternative
Studies on Neural Stem Cells and Differentiation after Transplantation into Central Nervous System.
Author
Mitome, Masato Department of Pediatric Dentistry, Institute of Health Biosciences, The University of Tokushima Graduate School
Keywords
神経幹細胞
移植
再生医療
中枢神経
咀嚼
Content Type
Journal Article
Description
Generation of neurons in the mammalian central nervous system (CNS) is believed to end by early postnatal life. However, neurogenesis has been demonstrated in different regions of both the developing and mature CNS. In such areas, neural stem cells and progenitor cells have been isolated using trophic factors. When the cells are cultured in a chemically defined, serum-free medium with epidermal growth factor (EGF) or basic fibroblast growth factor (FGF-2), they proliferate as cellular clusters floating in the medium (‘neurospheres’). In vitro, clonal analyses indicate that such cells can individually generate neurons, astrocytes and oligodendrocytes. Cells from expanded neurosphere cultures are grafted into valious regions of CNS, including hypothalamus, hippocampus, medulla oblongata and subventricular zone. FGF-2 and EGF-responsive cells differentitate predominantly give rise to glial cells. Some of FGF-2-responsive cells transplanted into neurogenic regions of mouse brain differentiate into region-specific neurons. The characters and relative advantages of these cells for cell replacement therapy are discussed.
Journal Title
四国歯学会雑誌
ISSN
09146091
NCID
AN10050046
Publisher
四国歯学会
Volume
20
Issue
2
Start Page
199
End Page
206
Sort Key
199
Published Date
2008-01-31
FullText File
language
jpn
TextVersion
Publisher