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ID 109763
タイトルヨミ
シンケイ カンサイボウ ノ セイシツ ト イショクゴ ノ ブンカ ドウタイ ニツイテ
タイトル別表記
Studies on Neural Stem Cells and Differentiation after Transplantation into Central Nervous System.
著者
三留, 雅人 徳島大学大学院ヘルスバイオサイエンス研究部小児口腔健康科学分野
キーワード
神経幹細胞
移植
再生医療
中枢神経
咀嚼
資料タイプ
学術雑誌論文
抄録
Generation of neurons in the mammalian central nervous system (CNS) is believed to end by early postnatal life. However, neurogenesis has been demonstrated in different regions of both the developing and mature CNS. In such areas, neural stem cells and progenitor cells have been isolated using trophic factors. When the cells are cultured in a chemically defined, serum-free medium with epidermal growth factor (EGF) or basic fibroblast growth factor (FGF-2), they proliferate as cellular clusters floating in the medium (‘neurospheres’). In vitro, clonal analyses indicate that such cells can individually generate neurons, astrocytes and oligodendrocytes. Cells from expanded neurosphere cultures are grafted into valious regions of CNS, including hypothalamus, hippocampus, medulla oblongata and subventricular zone. FGF-2 and EGF-responsive cells differentitate predominantly give rise to glial cells. Some of FGF-2-responsive cells transplanted into neurogenic regions of mouse brain differentiate into region-specific neurons. The characters and relative advantages of these cells for cell replacement therapy are discussed.
掲載誌名
四国歯学会雑誌
ISSN
09146091
cat書誌ID
AN10050046
出版者
四国歯学会
20
2
開始ページ
199
終了ページ
206
並び順
199
発行日
2008-01-31
フルテキストファイル
言語
jpn
著者版フラグ
出版社版