ID 109803
Title Transcription
トクテイ ハチョウコウ ノ ショウシャ ニヨル Porphyromonas gingivalis ノ ゾウショク ヨクセイ コウカ
Title Alternative
Specific-wavelength Visible Light Irradiation Inhibits Bacterial Growth of Porphyromonas gingivalis
Author
Fukui, Makoto Department of Preventive Dentistry, Institute of Health Biosciences, The University of Tokushima Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Keywords
光線力学療法
Porphyromonas gingivalis
歯周病
Content Type
Journal Article
Description
Photodynamic therapy was originally reported as a treatment of malignant tumors using photosensitive agents (photosensitizers) and visible light irradiation. When a tumor tissue containing a photosensitizer is irradiated with light of an appropriate wavelength and dose, a photochemical reaction is induced and the activated photosensitizer produces free radicals that damage cells and cause necrosis of the tumor. Recently, this technique has also been shown to be effective for inhibiting bacterial growth. Porphyromonas gingivalis, a periodontal pathogenic bacterium, produces endogenous protoporphyrin by degrading hemoglobin for its growth, which could make this bacterium photosensitive. Therefore, photodynamic therapy for periodontal diseases targeting this bacterium without using exogenous photosensitizer is expected. The effects of light irradiation on P. gingivalis have been reported, however the optimal irradiation condition remains to be determined in terms of the light sources, wavelength, and other parameters. Recently, we demonstrated that P. gingivalis growth was inhibited by visible laser light irradiation at 405 nm and an energy density of 15 J/cm2 without the use of any exogenous photosensitizers. These findings suggest that photodynamic therapy without any exogenous photosensitizer is a promising novel technology for the control of periodontal diseases.
Journal Title
四国歯学会雑誌
ISSN
09146091
NCID
AN10050046
Publisher
四国歯学会
Volume
23
Issue
2
Start Page
91
End Page
96
Sort Key
91
Published Date
2011-01-31
EDB ID
FullText File
language
jpn
TextVersion
Publisher
departments
Oral Sciences