ID 109803
タイトルヨミ
トクテイ ハチョウコウ ノ ショウシャ ニヨル Porphyromonas gingivalis ノ ゾウショク ヨクセイ コウカ
タイトル別表記
Specific-wavelength Visible Light Irradiation Inhibits Bacterial Growth of Porphyromonas gingivalis
著者
福井, 誠 徳島大学大学院ヘルスバイオサイエンス研究部予防歯学分野 徳島大学 教育研究者総覧 KAKEN研究者をさがす
キーワード
光線力学療法
Porphyromonas gingivalis
歯周病
資料タイプ
学術雑誌論文
抄録
Photodynamic therapy was originally reported as a treatment of malignant tumors using photosensitive agents (photosensitizers) and visible light irradiation. When a tumor tissue containing a photosensitizer is irradiated with light of an appropriate wavelength and dose, a photochemical reaction is induced and the activated photosensitizer produces free radicals that damage cells and cause necrosis of the tumor. Recently, this technique has also been shown to be effective for inhibiting bacterial growth. Porphyromonas gingivalis, a periodontal pathogenic bacterium, produces endogenous protoporphyrin by degrading hemoglobin for its growth, which could make this bacterium photosensitive. Therefore, photodynamic therapy for periodontal diseases targeting this bacterium without using exogenous photosensitizer is expected. The effects of light irradiation on P. gingivalis have been reported, however the optimal irradiation condition remains to be determined in terms of the light sources, wavelength, and other parameters. Recently, we demonstrated that P. gingivalis growth was inhibited by visible laser light irradiation at 405 nm and an energy density of 15 J/cm2 without the use of any exogenous photosensitizers. These findings suggest that photodynamic therapy without any exogenous photosensitizer is a promising novel technology for the control of periodontal diseases.
掲載誌名
四国歯学会雑誌
ISSN
09146091
cat書誌ID
AN10050046
出版者
四国歯学会
23
2
開始ページ
91
終了ページ
96
並び順
91
発行日
2011-01-31
EDB ID
フルテキストファイル
言語
jpn
著者版フラグ
出版社版
部局
歯学系