ID 109837
Title Transcription
エナメルシツ ケイセイ フゼンショウ ノ シンキ セキニン イデンシ ヘンイ ノ ハッケン ト ソノ イギ : テンシャ インシ Sp6 オ メグル パズル
Title Alternative
Novel Finding of Genetic Linkage between Sp6 Mutation and Amelogenesis Imperfecta, and Beyond : Puzzles of Transcription Factor Sp6
Author
Miyoshi, Keiko Department of Molecular Biology, Institute of Health Biosciences, The University of Tokushima Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Keywords
エナメル質形成不全症
AMI
SP6
フレームシフト変異
アメロジェネシス
Content Type
Journal Article
Description
Tooth is one of the essential organs in our body, and plays the important roles to maintain and improve our quality of life (QOL). Regenerative medicine has been achieving the remarkable progress for several years, and tooth is also one of the hot research targets for regeneration therapy. To regenerate tooth, we need to understand whole tooth developmental program at molecular level. Reverse genetics has brought us many molecular details at the early stage of tooth development, however, the late stage of tooth development is not fully understood. We are now trying to elucidate the molecular paradigm on the development of dental epithelial cells.
During these studies, we found the new genetic linkage between amelogenesis imperfecta (AI) and a 2-bp insertional mutation of transcription factor Sp6, and proposed it as a new molecular diagnostic candidate for AI patients.
In this review, I would like to summarize about AI based on the responsible genes including current topics in the late stage of tooth development, and to discuss about what we can learn from those for regenerative tooth and future direction.
Journal Title
四国歯学会雑誌
ISSN
09146091
NCID
AN10050046
Publisher
四国歯学会
Volume
26
Issue
1
Start Page
1
End Page
10
Sort Key
1
Published Date
2013-07-17
EDB ID
FullText File
language
jpn
TextVersion
Publisher
departments
Oral Sciences