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ID 109837
タイトルヨミ
エナメルシツ ケイセイ フゼンショウ ノ シンキ セキニン イデンシ ヘンイ ノ ハッケン ト ソノ イギ : テンシャ インシ Sp6 オ メグル パズル
タイトル別表記
Novel Finding of Genetic Linkage between Sp6 Mutation and Amelogenesis Imperfecta, and Beyond : Puzzles of Transcription Factor Sp6
著者
三好, 圭子 徳島大学大学院ヘルスバイオサイエンス研究部分子医化学分野 徳島大学 教育研究者総覧 KAKEN研究者をさがす
キーワード
エナメル質形成不全症
AMI
SP6
フレームシフト変異
アメロジェネシス
資料タイプ
学術雑誌論文
抄録
Tooth is one of the essential organs in our body, and plays the important roles to maintain and improve our quality of life (QOL). Regenerative medicine has been achieving the remarkable progress for several years, and tooth is also one of the hot research targets for regeneration therapy. To regenerate tooth, we need to understand whole tooth developmental program at molecular level. Reverse genetics has brought us many molecular details at the early stage of tooth development, however, the late stage of tooth development is not fully understood. We are now trying to elucidate the molecular paradigm on the development of dental epithelial cells.
During these studies, we found the new genetic linkage between amelogenesis imperfecta (AI) and a 2-bp insertional mutation of transcription factor Sp6, and proposed it as a new molecular diagnostic candidate for AI patients.
In this review, I would like to summarize about AI based on the responsible genes including current topics in the late stage of tooth development, and to discuss about what we can learn from those for regenerative tooth and future direction.
掲載誌名
四国歯学会雑誌
ISSN
09146091
cat書誌ID
AN10050046
出版者
四国歯学会
26
1
開始ページ
1
終了ページ
10
並び順
1
発行日
2013-07-17
EDB ID
フルテキストファイル
言語
jpn
著者版フラグ
出版社版
部局
歯学系