ID 109840
Title Transcription
ゾウゲガ サイボウ ノ ブンカ ト サイボウガイ キシツ
Title Alternative
Role of Extracellular Matrix in Odontoblast Differentiation
Author
Iwamoto, Tsutomu Department of Pediatric Dentistry, Institute of Health Biosciences, The University of Tokushima Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Keywords
象牙芽細胞
象牙質
細胞外基質
Content Type
Journal Article
Description
Tooth development is a complex process that includes interactions between oral epithelium-derived dental epithelial cells and neural crest-derived dental mesenchymal cells. In this process, the basement membrane at the epithelial-mesenchymal interface plays important roles in matrix-mediated cell interactions and for trapping growth factors, then dental epithelial and mesenchymal cells differentiate into enamel-forming ameloblasts and dentin-forming odontoblasts, respectively. For enamel and dentin formation, these cells produce large amounts of extracellular matrixes, thus cell-matrix and cell-cell interactions are crucial for both ameloblast and odontoblast differentiation. In this review, we focus on the role of the extracellular matrix in odontoblast differentiation. Dentin and bone are similar in several aspects, such as extracellular matrix composition and genetic diseases, which affect both bone and dentin mineralization, common between them. However, the process of odontoblast differentiation is completely different from that of osteoblast differentiation. For better understanding of tooth development, it is important to elucidate the differences between these cell types.
Journal Title
四国歯学会雑誌
ISSN
09146091
NCID
AN10050046
Publisher
四国歯学会
Volume
26
Issue
2
Start Page
23
End Page
28
Sort Key
23
Published Date
2014-02-14
EDB ID
FullText File
language
jpn
TextVersion
Publisher
departments
Oral Sciences