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ID 110037
Title Alternative
腎発生におけるプロレニン、プロレニン受容体の役割検討
Soluble (pro)renin receptor in neonates
Author
Terada, Tomomasa Tokushima University
Saijo, Takahiko Tokushima University
Keywords
Renin-angiotensin
Gestational age
Cord blood
Enzyme-linked immunosorbent assay
Immunohistochemistry
Content Type
Thesis or Dissertation
Description
Although a recent study demonstrated that the (pro)renin receptor ((P)RR) was highly expressed in the developing kidney during the mouse embryonic development, the mechanism by which (P)RR supports renal development in humans is not fully understood. In this study, we examined the plasma levels of (pro)renin and soluble (P)RR (s(P)RR) in cord blood and neonates as well as (P)RR expression in human kidney tissues. Samples were collected from 57 preterm and 67 full-term human neonates. (Pro)renin and s(P)RR levels were measured using enzyme-linked immunosorbent assays. Additionally, we performed an immunohistochemical (IHC) analysis of kidney tissues from neonates and minor glomerular abnormalities in order to assess (P)RR expression in the kidney. Plasma (pro)renin and s(P)RR levels in cord blood were significantly higher in preterm neonates than in full-term neonates. Four weeks after birth, these differences were no longer evident for either plasma (pro)renin or s(P)RR levels between the two groups. Importantly, plasma (pro)renin and s(P)RR levels in cord blood were inversely correlated with gestational age. Furthermore, IHC indicated that renal expression levels of (P)RR in neonates was stronger than that in minor glomerular abnormalities.
Conclusion: (P)RR may play a pivotal role in prenatal renal development in humans.
Journal Title
European Journal of Pediatrics
ISSN
03406199
14321076
NCID
AA00639676
AA11622857
Publisher
Springer Berlin Heidelberg
Volume
176
Issue
2
Start Page
183
End Page
189
Published Date
2016-12-19
Remark
内容要旨・審査要旨・論文本文の公開:
内容要旨・審査要旨:LID201704131003.pdf
論文本文: k3013_fulltext.pdf
本論文は, 著者Tomomasa Teradaの学位論文として提出され, 学位審査・授与の対象となっている。
The final publication is available at link.springer.com.
EDB ID
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
ETD
MEXT report number
甲第3013号
Diploma Number
甲医第1317号
Granted Date
2017-03-23
Degree Name
Doctor of Medical Science
Grantor
Tokushima University
departments
University Hospital
Medical Sciences