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ID 110037
タイトル別表記
腎発生におけるプロレニン、プロレニン受容体の役割検討
Soluble (pro)renin receptor in neonates
著者
寺田, 知正 徳島大学大学院医科学教育部(医学専攻)
Saijo, Takahiko Tokushima University
キーワード
Renin-angiotensin
Gestational age
Cord blood
Enzyme-linked immunosorbent assay
Immunohistochemistry
資料タイプ
学位論文
抄録
Although a recent study demonstrated that the (pro)renin receptor ((P)RR) was highly expressed in the developing kidney during the mouse embryonic development, the mechanism by which (P)RR supports renal development in humans is not fully understood. In this study, we examined the plasma levels of (pro)renin and soluble (P)RR (s(P)RR) in cord blood and neonates as well as (P)RR expression in human kidney tissues. Samples were collected from 57 preterm and 67 full-term human neonates. (Pro)renin and s(P)RR levels were measured using enzyme-linked immunosorbent assays. Additionally, we performed an immunohistochemical (IHC) analysis of kidney tissues from neonates and minor glomerular abnormalities in order to assess (P)RR expression in the kidney. Plasma (pro)renin and s(P)RR levels in cord blood were significantly higher in preterm neonates than in full-term neonates. Four weeks after birth, these differences were no longer evident for either plasma (pro)renin or s(P)RR levels between the two groups. Importantly, plasma (pro)renin and s(P)RR levels in cord blood were inversely correlated with gestational age. Furthermore, IHC indicated that renal expression levels of (P)RR in neonates was stronger than that in minor glomerular abnormalities.
Conclusion: (P)RR may play a pivotal role in prenatal renal development in humans.
掲載誌名
European Journal of Pediatrics
ISSN
03406199
14321076
cat書誌ID
AA00639676
AA11622857
出版者
Springer Berlin Heidelberg
176
2
開始ページ
183
終了ページ
189
発行日
2016-12-19
備考
内容要旨・審査要旨・論文本文の公開:
内容要旨・審査要旨:LID201704131003.pdf
論文本文: k3013_fulltext.pdf
本論文は, 著者Tomomasa Teradaの学位論文として提出され, 学位審査・授与の対象となっている。
The final publication is available at link.springer.com.
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
博士論文全文を含む
文科省報告番号
甲第3013号
学位記番号
甲医第1317号
学位授与年月日
2017-03-23
学位名
博士(医学)
学位授与機関
徳島大学
部局
病院
医学系