ID 110051
Author
Tsuzuki, Hiromitsu Graduate School of Integrated Arts and Sciences, Tokushima University
Inoue, Shota Graduate School of Integrated Arts and Sciences, Tokushima University
Kobayashi, Daiki Graduate School of Integrated Arts and Sciences, Tokushima University
Uuganbaatar, Gantulga Graduate School of Integrated Arts and Sciences, Tokushima University
Oyama, Yasuo Faculty of Bioscience and Bioindustry, Tokushima University Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Keywords
Methyl cinnamate
Hydrogen peroxide
Cytotoxicity
Lymphocytes
Oxidative stress
Content Type
Journal Article
Description
Methyl cinnamate (MC) and essential oils containing MC possess beneficial antimicrobial, antifungal, and insecticidal effects, among ohters. Such effects are related to the biocidal action of MC. The antioxidant activity of MC has also been reported elsewhere. It has been suggested that MC may be cytotoxic to cells exposed to oxidative stress. To test this possibility, the effect of MC on rat thymocytes was examined while the cells were subjected to oxidative stress induced by hydrogen peroxide (H2O2). Flow cytometric techniques with appropriate fluorescent probes were used for quantification. MC increased cell vulnerability to oxidative stress via acceleration of the cell death process and/or poteniation of oxidative stress. The use of MC is widespread because of its beneficial actions, and thus further attention should be paid to whether MC is effective under oxidative stress.
Journal Title
Fundamental Toxicological Sciences
ISSN
2189115X
Volume
3
Issue
3
Start Page
121
End Page
125
Sort Key
121
Published Date
2016
Remark
Copyright © 2016 The Japanese Society of Toxicology
EDB ID
Published Source
Fundamental Toxicological Sciences (2016) Vol.3 No.3 p.121-125
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
Publisher
departments
Bioscience and Bioindustry