ID 110168
Author
Kozai, Mina Division of Experimental Immunology, Institute of Advanced Medical Sciences, University of Tokushima KAKEN Search Researchers
Kubo, Yuki Division of Experimental Immunology, Institute of Advanced Medical Sciences, University of Tokushima|Student Laboratory, School of Medicine, University of Tokushima
Katakai, Tomoya Department of Immunology, Graduate School of Medical and Dental Sciences, Niigata University
Kondo, Hiroyuki Division of Experimental Immunology, Institute of Advanced Medical Sciences, University of Tokushima
Kiyonari, Hiroshi Animal Resource Development Unit and Genetic Engineering Team, Institute of Physical and Chemical Research Center for Life Science Technologies
Schaeuble, Karin Department of Biochemistry, Center for Immunity and Infection, University of Lausanne
Luther, Sanjiv A. Department of Biochemistry, Center for Immunity and Infection, University of Lausanne
Ishimaru, Naozumi Division of Molecular Pathology, Graduate School of Oral Sciences, University of Tokushima Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Ohigashi, Izumi Division of Experimental Immunology, Institute of Advanced Medical Sciences, University of Tokushima Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Takahama, Yousuke Division of Experimental Immunology, Institute of Advanced Medical Sciences, University of Tokushima Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Content Type
Journal Article
Description
The chemokine receptor CCR7 directs T cell relocation into and within lymphoid organs, including the migration of developing thymocytes into the thymic medulla. However, how three functional CCR7 ligands in mouse, CCL19, CCL21Ser, and CCL21Leu, divide their roles in immune organs is unclear. By producing mice specifically deficient in CCL21Ser, we show that CCL21Ser is essential for the accumulation of positively selected thymocytes in the thymic medulla. CCL21Ser-deficient mice were impaired in the medullary deletion of self-reactive thymocytes and developed autoimmune dacryoadenitis. T cell accumulation in the lymph nodes was also defective. These results indicate a nonredundant role of CCL21Ser in the establishment of selftolerance in T cells in the thymic medulla, and reveal a functional inequality among CCR7 ligands in vivo.
Journal Title
Journal of Experimental Medicine
ISSN
15409538
00221007
NCID
AA12119243
AA00697559
Publisher
Rockefeller University Press
Volume
214
Issue
7
Start Page
1925
End Page
1935
Published Date
2017-06-13
Remark
© 2017 Kozai et al. This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org /terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial– Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/)
EDB ID
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
Publisher
departments
Oral Sciences
Institute of Advanced Medical Sciences