ID 110168
著者
コウザイ, ミナ Division of Experimental Immunology, Institute of Advanced Medical Sciences, University of Tokushima KAKEN研究者をさがす
クボ, ユキ Division of Experimental Immunology, Institute of Advanced Medical Sciences, University of Tokushima|Student Laboratory, School of Medicine, University of Tokushima
カタカイ, トモヤ Department of Immunology, Graduate School of Medical and Dental Sciences, Niigata University
コンドウ, ヒロユキ Division of Experimental Immunology, Institute of Advanced Medical Sciences, University of Tokushima
キヨナリ, ヒロシ Animal Resource Development Unit and Genetic Engineering Team, Institute of Physical and Chemical Research Center for Life Science Technologies
Schaeuble, Karin Department of Biochemistry, Center for Immunity and Infection, University of Lausanne
Luther, Sanjiv A. Department of Biochemistry, Center for Immunity and Infection, University of Lausanne
石丸, 直澄 Division of Molecular Pathology, Graduate School of Oral Sciences, University of Tokushima 徳島大学 教育研究者総覧 KAKEN研究者をさがす
大東, いずみ Division of Experimental Immunology, Institute of Advanced Medical Sciences, University of Tokushima 徳島大学 教育研究者総覧 KAKEN研究者をさがす
高浜, 洋介 Division of Experimental Immunology, Institute of Advanced Medical Sciences, University of Tokushima 徳島大学 教育研究者総覧 KAKEN研究者をさがす
資料タイプ
学術雑誌論文
抄録
The chemokine receptor CCR7 directs T cell relocation into and within lymphoid organs, including the migration of developing thymocytes into the thymic medulla. However, how three functional CCR7 ligands in mouse, CCL19, CCL21Ser, and CCL21Leu, divide their roles in immune organs is unclear. By producing mice specifically deficient in CCL21Ser, we show that CCL21Ser is essential for the accumulation of positively selected thymocytes in the thymic medulla. CCL21Ser-deficient mice were impaired in the medullary deletion of self-reactive thymocytes and developed autoimmune dacryoadenitis. T cell accumulation in the lymph nodes was also defective. These results indicate a nonredundant role of CCL21Ser in the establishment of selftolerance in T cells in the thymic medulla, and reveal a functional inequality among CCR7 ligands in vivo.
掲載誌名
Journal of Experimental Medicine
ISSN
15409538
00221007
cat書誌ID
AA12119243
AA00697559
出版者
Rockefeller University Press
214
7
開始ページ
1925
終了ページ
1935
発行日
2017-06-13
備考
© 2017 Kozai et al. This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org /terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial– Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/)
EDB ID
325872
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
歯学系
先端酵素学研究所