ID 110181
Author
Hossain, Md. Golam Department of Medical Pharmacology, Institute of Health Biosciences, the University of Tokushima Graduate School
Iwata, Takeo Department of Medical Pharmacology, Institute of Health Biosciences, the University of Tokushima Graduate School KAKEN Search Researchers
Mizusawa, Noriko Department of Medical Pharmacology, Institute of Health Biosciences, the University of Tokushima Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Qian, Zhi Rong Department of Human Pathology, Institute of Health Biosciences, the University of Tokushima Graduate School
Yamada, Shozo Department of Hypothalamic and Pituitary Surgery, Toranomon Hospital
Sano, Toshiaki Department of Human Pathology, Institute of Health Biosciences, the University of Tokushima Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Yoshimoto, Katsuhiko Department of Medical Pharmacology, Institute of Health Biosciences, the University of Tokushima Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Keywords
pituitary adenomas
CKIs
INK4 family
Cip/Kip family
mutations
promoter methylation
Content Type
Journal Article
Description
Human pituitary adenomas are common and potentially serious neoplasms that account for 10- 15% of all intracranial neoplasms. In spite of extensive investigations, the molecular basis of human pituitary tumorigenesis remains elusive. The cell cycle is driven by protein complexes composed of cyclins and cyclin-dependent kinases(CDKs). CDK inhibitors(CKIs)serve as negative regulators of cell cycle. CKIs include two distinct families : the INK4 family comprising p16INK4A, p15INK4B, p18INK4C, and p19INK4D and the Cip/Kip family including p21CIP1, p27KIP1, and p57KIP2. Dysregulation in CKIs are recognized as critical factors in tumorigenesis. In recent years, extensive studies have demonstrated that mutations, underexpression, and DNA methylation of the CKIs genes were frequently observed in various types of human cancers. However, the role of CKIs in human pituitary tumors has been elucidated to a limited extent. Here we review the potential role of CKIs in human pituitary adenomas concentrating on gene mutations, promoter methylation, and mRNA or protein expression levels.
Journal Title
四国医学雑誌
ISSN
00373699
NCID
AN00102041
Volume
64
Issue
5-6
Start Page
225
End Page
231
Sort Key
225
Published Date
2008-12-20
EDB ID
FullText File
language
eng
TextVersion
Publisher
departments
Oral Sciences
Medical Sciences