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ID 110181
著者
Hossain, Md. Golam Department of Medical Pharmacology, Institute of Health Biosciences, the University of Tokushima Graduate School
岩田, 武男 Department of Medical Pharmacology, Institute of Health Biosciences, the University of Tokushima Graduate School KAKEN研究者をさがす
水澤, 典子 Department of Medical Pharmacology, Institute of Health Biosciences, the University of Tokushima Graduate School 徳島大学 教育研究者総覧 KAKEN研究者をさがす
Qian, Zhi Rong Department of Human Pathology, Institute of Health Biosciences, the University of Tokushima Graduate School
ヤマダ, ショウゾウ Department of Hypothalamic and Pituitary Surgery, Toranomon Hospital
佐野, 壽昭 Department of Human Pathology, Institute of Health Biosciences, the University of Tokushima Graduate School 徳島大学 教育研究者総覧 KAKEN研究者をさがす
吉本, 勝彦 Department of Medical Pharmacology, Institute of Health Biosciences, the University of Tokushima Graduate School 徳島大学 教育研究者総覧 KAKEN研究者をさがす
キーワード
pituitary adenomas
CKIs
INK4 family
Cip/Kip family
mutations
promoter methylation
資料タイプ
学術雑誌論文
抄録
Human pituitary adenomas are common and potentially serious neoplasms that account for 10- 15% of all intracranial neoplasms. In spite of extensive investigations, the molecular basis of human pituitary tumorigenesis remains elusive. The cell cycle is driven by protein complexes composed of cyclins and cyclin-dependent kinases(CDKs). CDK inhibitors(CKIs)serve as negative regulators of cell cycle. CKIs include two distinct families : the INK4 family comprising p16INK4A, p15INK4B, p18INK4C, and p19INK4D and the Cip/Kip family including p21CIP1, p27KIP1, and p57KIP2. Dysregulation in CKIs are recognized as critical factors in tumorigenesis. In recent years, extensive studies have demonstrated that mutations, underexpression, and DNA methylation of the CKIs genes were frequently observed in various types of human cancers. However, the role of CKIs in human pituitary tumors has been elucidated to a limited extent. Here we review the potential role of CKIs in human pituitary adenomas concentrating on gene mutations, promoter methylation, and mRNA or protein expression levels.
掲載誌名
四国医学雑誌
ISSN
00373699
cat書誌ID
AN00102041
64
5-6
開始ページ
225
終了ページ
231
並び順
225
発行日
2008-12-20
EDB ID
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
歯学系
医学系