ID 110299
Title Transcription
カワサキビョウ ワ イマ モ フエツズケテ イル : トクシマケンカ 10ネンカン ノ シュウケイ
Title Alternative
Incidence rate of Kawasaki Disease is increasing, still now : survey for 10-years in Tokushima Prefecture
Author
Matsuoka, Suguru Tokushima Meeting for Kawasaki Disease|Tokushima Municipal Hospital
Mori, Kazuhiro Tokushima Meeting for Kawasaki Disease|Tokushima Municipal Hospital
Yuasa, Yasuhito Tokushima Meeting for Kawasaki Disease|Tokushima Prefectural Central Hospital
Kubo, Masahiro Tokushima Meeting for Kawasaki Disease|Tokushima Prefectural Central Hospital
Yoshida, Tetsuya Tokushima Meeting for Kawasaki Disease|Tokushima Red Cross Hospital
Nakatsu, Tadanori Tokushima Meeting for Kawasaki Disease|Tokushima Red Cross Hospital
Ichioka, Takao Tokushima Meeting for Kawasaki Disease|Naruto Health Insurance Hospital
Yamada, Tadashi Tokushima Meeting for Kawasaki Disease|Oe Kyoudou Hospital
Ueda, Takashi Tokushima Meeting for Kawasaki Disease|Anan Kyouei Hospital
Satou, Noboru Tokushima Meeting for Kawasaki Disease|Awa Hospital
Inoue, Miki Tokushima Meeting for Kawasaki Disease|Department of Pediatrics,Tokushima University Hospital
Hayabuchi, Yasunobu Tokushima Meeting for Kawasaki Disease|Department of Pediatrics,Tokushima University Hospital Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Keywords
Kawasaki disease
incidence
Content Type
Journal Article
Description
Tomisaku Kawasaki saw his first case of unusual illness in a four-year-old with high fever, bilateral nonexudative conjunctivitis, redness of the lips and oral mucosa, a rash and cervical lymphadenopathy in 1961, and published in 1967. The cause of Kawasaki Disease(KD)has not known yet. In 1963, we saw a first case in Tokushima. The incidence rates per 100,000 children younger than the age of five have been steadily increasing, involving with two big prevalence in 1982 and 1986. From 1999, we enrolled 643 patients with KD for 10 years in Tokushima Prefecture. Most cases 88% were less than 5 years old and a peak incidence in children from 0 to 2 years old. KD has been more popular in winter season(1.5 times)than in other seasons. These suggest that both genetic susceptibility and environmental factors play a role in KD. In Tokushima, coronary artery aneurysm developed in 1.1%(2.4% in all Japan). Aneurysm persist and become occlusive, thereby increasing the risk of atherosclerosis, myocardial infarction or sudden cardiac death. In 1999, the standard treatment for acute-phase KD was a 5-days regimen of intravenous(IV) gammmaglobulin(200 mg/kg/day), supplemented with aspirin. Now, a single infusion of IV gammaglobulin( 2 g/kg)followed by low-dose aspirin therapy. Recent regimen is more effective, but the 11% recipients were non-responder in Tokushima(20% in all Japan). Therefor, further research is required to know the pathogenesis and host genetics in KD.
Journal Title
四国医学雑誌
ISSN
00373699
NCID
AN00102041
Publisher
徳島医学会
Volume
65
Issue
5-6
Start Page
177
End Page
180
Sort Key
177
Published Date
2009-12-20
FullText File
language
jpn
TextVersion
Publisher
departments
Medical Sciences