ID 110299
タイトルヨミ
カワサキビョウ ワ イマ モ フエツズケテ イル : トクシマケンカ 10ネンカン ノ シュウケイ
タイトル別表記
Incidence rate of Kawasaki Disease is increasing, still now : survey for 10-years in Tokushima Prefecture
著者
松岡, 優 徳島川崎病懇話会|徳島市民病院
森, 一博 徳島川崎病懇話会|徳島市民病院
湯浅, 安人 徳島川崎病懇話会|徳島県立中央病院
久保, 雅宏 徳島川崎病懇話会|徳島県立中央病院
吉田, 哲也 徳島川崎病懇話会|徳島赤十字病院
中津, 忠則 徳島川崎病懇話会|徳島赤十字病院
市岡, 隆男 徳島川崎病懇話会|鳴門健保病院
山田, 正 徳島川崎病懇話会|麻植協同病院
上田, 隆 徳島川崎病懇話会|阿南共栄病院
佐藤, 登 徳島川崎病懇話会|阿波病院
井上, 美紀 徳島川崎病懇話会|徳島大学病院
キーワード
Kawasaki disease
incidence
資料タイプ
学術雑誌論文
抄録
Tomisaku Kawasaki saw his first case of unusual illness in a four-year-old with high fever, bilateral nonexudative conjunctivitis, redness of the lips and oral mucosa, a rash and cervical lymphadenopathy in 1961, and published in 1967. The cause of Kawasaki Disease(KD)has not known yet. In 1963, we saw a first case in Tokushima. The incidence rates per 100,000 children younger than the age of five have been steadily increasing, involving with two big prevalence in 1982 and 1986. From 1999, we enrolled 643 patients with KD for 10 years in Tokushima Prefecture. Most cases 88% were less than 5 years old and a peak incidence in children from 0 to 2 years old. KD has been more popular in winter season(1.5 times)than in other seasons. These suggest that both genetic susceptibility and environmental factors play a role in KD. In Tokushima, coronary artery aneurysm developed in 1.1%(2.4% in all Japan). Aneurysm persist and become occlusive, thereby increasing the risk of atherosclerosis, myocardial infarction or sudden cardiac death. In 1999, the standard treatment for acute-phase KD was a 5-days regimen of intravenous(IV) gammmaglobulin(200 mg/kg/day), supplemented with aspirin. Now, a single infusion of IV gammaglobulin( 2 g/kg)followed by low-dose aspirin therapy. Recent regimen is more effective, but the 11% recipients were non-responder in Tokushima(20% in all Japan). Therefor, further research is required to know the pathogenesis and host genetics in KD.
掲載誌名
四国医学雑誌
ISSN
00373699
cat書誌ID
AN00102041
出版者
徳島医学会
65
5-6
開始ページ
177
終了ページ
180
並び順
177
発行日
2009-12-20
フルテキストファイル
言語
jpn
著者版フラグ
出版社版
部局
医学系