ID 110335
Title Transcription
カンドウミャク シッカン ノ ビョウタイ カイメイ ト アタラシイ シンダン チリョウ ギジュツ ノ カイハツ
Title Alternative
Pathogenesis of coronary artery diseases
Author
Sata, Masataka Department of Cardiovascular Medicine, Institute of Health Biosciences, the University of Tokushima Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Keywords
coronary artery disease
epicardial adipose tissue
angiogenesis
inflammation
obesity
Content Type
Journal Article
Description
Recent evidence suggests that acute coronary syndrome(ACS)results from plaque rupture in most of the cases. Vulnerable plaques are characterized by thinning of fibrous cap, increased lipid content, decreased smooth muscle cell content, and enhanced infiltration of inflammatory cells. However, the molecular mechanism of plaque destabilization is not fully understood. Thus, there is no established method to predict and prevent ACS. We have been studying the pathogenesis of plaque progression and destabilization, using animal models and clinical specimen. ApoE-deficient mice showed exaggerated atherosclerotic lesions with aging. Accumulation of macrophages in adventitia was first detected prior to plaque formation. Proliferation of vasa vasorum was observed only after atherosclerotic lesion formation. Local delivery of an angiogenic growth factor promoted lesion formation with enhanced neovascularization in the adventitia. Periadventitial fat is distributed ubiquitously around arteries. By using fat transplantation method, we found that periadventitial fat may protect against neointimal formation after angioplasty under physiological conditions and that inflammatory changes in the periadventitial fat may play a crucial role in the pathogenesis of vascular disease accelerated by obesity. Elucidation of the pathogenesis of coronary artery diseases leads to development of new strategies to diagnose and treat acute coronary syndrome.
Journal Title
四国医学雑誌
ISSN
00373699
NCID
AN00102041
Publisher
徳島医学会
Volume
66
Issue
5-6
Start Page
151
End Page
156
Sort Key
151
Published Date
2010-12-20
EDB ID
FullText File
language
jpn
TextVersion
Publisher
departments
Medical Sciences