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ID 110335
タイトルヨミ
カンドウミャク シッカン ノ ビョウタイ カイメイ ト アタラシイ シンダン チリョウ ギジュツ ノ カイハツ
タイトル別表記
Pathogenesis of coronary artery diseases
著者
佐田, 政隆 徳島大学大学院ヘルスバイオサイエンス研究部器官病態修復医学講座循環器内科学分野 徳島大学 教育研究者総覧 KAKEN研究者をさがす
キーワード
coronary artery disease
epicardial adipose tissue
angiogenesis
inflammation
obesity
資料タイプ
学術雑誌論文
抄録
Recent evidence suggests that acute coronary syndrome(ACS)results from plaque rupture in most of the cases. Vulnerable plaques are characterized by thinning of fibrous cap, increased lipid content, decreased smooth muscle cell content, and enhanced infiltration of inflammatory cells. However, the molecular mechanism of plaque destabilization is not fully understood. Thus, there is no established method to predict and prevent ACS. We have been studying the pathogenesis of plaque progression and destabilization, using animal models and clinical specimen. ApoE-deficient mice showed exaggerated atherosclerotic lesions with aging. Accumulation of macrophages in adventitia was first detected prior to plaque formation. Proliferation of vasa vasorum was observed only after atherosclerotic lesion formation. Local delivery of an angiogenic growth factor promoted lesion formation with enhanced neovascularization in the adventitia. Periadventitial fat is distributed ubiquitously around arteries. By using fat transplantation method, we found that periadventitial fat may protect against neointimal formation after angioplasty under physiological conditions and that inflammatory changes in the periadventitial fat may play a crucial role in the pathogenesis of vascular disease accelerated by obesity. Elucidation of the pathogenesis of coronary artery diseases leads to development of new strategies to diagnose and treat acute coronary syndrome.
掲載誌名
四国医学雑誌
ISSN
00373699
cat書誌ID
AN00102041
出版者
徳島医学会
66
5-6
開始ページ
151
終了ページ
156
並び順
151
発行日
2010-12-20
EDB ID
フルテキストファイル
言語
jpn
著者版フラグ
出版社版
部局
医学系