ID 110338
Title Transcription
ガン カガク リョウホウ ニオケル ショウカカン ドクセイ ト ケッセイ Diamine Oxidase DAO カッセイ ニ カンスル ケントウ
Title Alternative
Gastrointestinal toxicity and serum diamine oxidase (DAO) activity during chemotherapy
Author
Tamura, Ushio Post-graduate Education Center, Tokushima University Hospital
Okahisa, Toshiya Department of Gastroenterology and Oncology, the University of Tokushima Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Kitamura, Shinji Department of Gastroenterology and Oncology, the University of Tokushima Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Tonoiso, Chisato Post-graduate Education Center, Tokushima University Hospital Tokushima University Educator and Researcher Directory
Udaka, Kengo Post-graduate Education Center, Tokushima University Hospital
Kobayashi, Akimi Post-graduate Education Center, Tokushima University Hospital
Matsumoto, Sayo Post-graduate Education Center, Tokushima University Hospital
Miyamoto, Yasuo Post-graduate Education Center, Tokushima University Hospital
Arita, Kanako Department of Gastroenterology and Oncology, the University of Tokushima Graduate School
Kishi, Kumiko Department of Gastroenterology and Oncology, the University of Tokushima Graduate School
Nakamura, Fumika Department of Gastroenterology and Oncology, the University of Tokushima Graduate School
Miyoshi, Jinsei Department of Gastroenterology and Oncology, the University of Tokushima Graduate School Tokushima University Educator and Researcher Directory
Tanaka, Takahiro Department of Gastroenterology and Oncology, the University of Tokushima Graduate School Tokushima University Educator and Researcher Directory
Fujino, Yasuteru Department of Gastroenterology and Oncology, the University of Tokushima Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Inoue, Atsushi Department of Gastroenterology and Oncology, the University of Tokushima Graduate School
Yano, Hiromi Department of Gastroenterology and Oncology, the University of Tokushima Graduate School
Kimura, Tetsuo Department of Gastroenterology and Oncology, the University of Tokushima Graduate School KAKEN Search Researchers
Takeuchi, Hisashi Department of Gastroenterology and Oncology, the University of Tokushima Graduate School
Niki, Miyako Department of Gastroenterology and Oncology, the University of Tokushima Graduate School
Okamoto, Koichi Department of Gastroenterology and Oncology, the University of Tokushima Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Kimura, Masako Department of Gastroenterology and Oncology, the University of Tokushima Graduate School
Sato, Yasunori Department of Gastroenterology and Oncology, the University of Tokushima Graduate School
Okamura, Seisuke Department of Gastroenterology and Oncology, the University of Tokushima Graduate School
Nakaya, Yutaka Department of Nutrition and Metabolism, Institute of Health Biosciences, the University of Tokushima Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Takayama, Tetsuji Department of Gastroenterology and Oncology, the University of Tokushima Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Keywords
gastrointestinal toxicity
gastric cancer chemotherapy
diamine oxidase
Content Type
Journal Article
Description
There are so many patients with advanced gastric cancer who undergo systemic chemotherapy worldwide. The quality of life(QOL)of patients with gastric cancer who receive chemotherapy is often lowed by various gastrointestinal toxicities during the chemotherapy. Nutrition is also impaired by gastrointestinal toxicities. However, it is difficult to predict their occurrence in advance and further there is no good serum marker for nutrition in the patients treated with chemotherapy. Thus, it is important to objectively evaluate and predict the toxicity of the digestive tract during cancer chemotherapy. Diamine Oxidase(DAO)is an enzyme that is expressed in intestinal epithelial cells. Recently it has been reported that DAO activity may reflect damage or atrophy of the intestinal villi, and therefore it may be a sensitive serum marker for nutritional state. In this study, we measured serum DAO activity of patients with gastric cancer treated with systemic chemotherapy, and investigated the correlation between DAO activity and gastrointestinal toxicities. Six patients with gastric cancer, who were treated by docetaxel+cisplatin+S‐1combination chemotherapy, were enrolled. DAO activity was measured by sensitive colorimetric assay. DAO activities diminished after treatment in4patients with moderate to severe gastrointestinal toxicities. In contrast, they did not change in2patients with no gastrointestinal toxicities. Our results may suggest that DAO activity is a good serum marker for the gastrointestinal toxicities as well as nutrition state in patients who receive systemic chemotherapy. More large scale study is needed to warrant.
Journal Title
四国医学雑誌
ISSN
00373699
NCID
AN00102041
Publisher
徳島医学会
Volume
66
Issue
5-6
Start Page
169
End Page
174
Sort Key
169
Published Date
2010-12-20
FullText File
language
jpn
TextVersion
Publisher
departments
Medical Sciences
University Hospital