ID 110344
Title Transcription
セイタイ ノ テイサンソ オウトウ ト ビョウタイ : ケッカン リモデリング ニオケル テンシャ インシ HIF ノ カンヨ「
Title Alternative
Role of Hypoxia-Inducible Factor1α (HIF-1α) in T cells in development of vascular remodeling
Author
Tomita, Shuhei Department of Pharmacology, Institute of Health Biosciences, the University of Tokushima Graduate School
Imanishi, Masaki Department of Pharmacology, Institute of Health Biosciences, the University of Tokushima Graduate School Tokushima University Educator and Researcher Directory
Sakurada, Takumi Department of Pharmacology, Institute of Health Biosciences, the University of Tokushima Graduate School
Yamano, Noriko Department of Pharmacology, Institute of Health Biosciences, the University of Tokushima Graduate School KAKEN Search Researchers
Kihira, Yoshitaka Department of Pharmacology, Institute of Health Biosciences, the University of Tokushima Graduate School
Ikeda, Yasumasa Department of Pharmacology, Institute of Health Biosciences, the University of Tokushima Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Tamaki, Toshiaki Department of Pharmacology, Institute of Health Biosciences, the University of Tokushima Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Keywords
vascular remodeling
hypoxia
hypoxia-inducible factor
Content Type
Journal Article
Description
Recent studies have shown that the cellular immune response to the hypoxic microenvironment constructed by vascular remodeling development modulates the resulting pathologic alterations. A major mechanism mediating adaptive responses to reduced oxygen availability is the regulation of transcription by hypoxia-inducible factor1(HIF‐1). Impairment of HIF‐1‐ dependent inflammatory responses in T cells causes an augmented vascular remodeling induced by arterial injury, which is shown as prominent neointimal hyperplasia and increase in infiltration of inflammatory cells at the adventitia in mice lacking Hif‐1α specifically in T cells. Studies to clarify the mechanism of augmented vascular remodeling in the mutant mice have shown enhanced production of cytokines in activated T cells and augmented antibody production in response to a T-dependent antigen in the mutant mice. This minireview shows that HIF‐1α in T cells plays a crucial role in vascular inflammation and remodeling in response to cuff injury as a negative regulator of the T cell-mediated immune response and suggests potential new therapeutic strategies that target HIF‐1α.
Journal Title
四国医学雑誌
ISSN
00373699
NCID
AN00102041
Publisher
徳島医学会
Volume
67
Issue
1-2
Start Page
3
End Page
6
Sort Key
3
Published Date
2011-04-25
EDB ID
FullText File
language
jpn
TextVersion
Publisher
departments
University Hospital
Bioscience and Bioindustry
Medical Sciences