ID 110345
Title Transcription
テイサンソ ヒョウテキ ヤクザイ ノ メディシナル ブリコラージュ ト ジセダイ イヤクヒン ボロン トレースドラッグ ノ ソウセイ
Title Alternative
Medicinal bricolage design of hypoxia-targeting drugs and invention of boron tracedrugs as next-generation universal drugs
Author
Hori, Hitoshi Department of Life System, Institute of Technology and Science, the University of Tokushima Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Uto, Yoshihiro Department of Life System, Institute of Technology and Science, the University of Tokushima Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Nakata, Eiji Department of Life System, Institute of Technology and Science, the University of Tokushima Graduate School|Institute of Advanced Energy, Kyoto University
Keywords
hypoxia-targeting antitumor drug
hypoxic cell radiosensitizer
hypoxic cytotoxin
boron tracedrug
neutron dynamic therapy
Content Type
Journal Article
Description
Hypoxia is now considered a fundamentally important characteristic of the tumor microenvironment. A discovery of the hypoxia inducible factor(HIF)has led to a rapidly increasing understanding of the molecular mechanisms involved in tumor hypoxia. This in turn has led to the current extensive interest in the signal molecules related to tumor hypoxia as potential molecular targets for cancer therapeutics. In this paper we give a medicinal bricolage overview of recent advances in hypoxia-targeting drugs research. These hypoxia-targeting drugs include antiangiogenic- and sugar-hybrid-hypoxic cell radiosensitizers and hypoxic cytotoxins, hypoxia-targeting boron neutron capture therapy(BNCT)drugs. The evaluation of ADME-tox and pharmacokinetic properties of drugs are extremely important and essential in their discovery process and their lifetime. Traditionally, as well known traceable drugs, their radiolabeled compounds have been studied for their purposes. However, there are some inherent problems such as their half-life and regulation of experimental facilities. For the purpose of overcoming these problems and creating drugs with functions required for systems biology or emerging physiology, we designed, as a traceable nextgeneration drug model, wholly innovative drugs named“boron tracedrug,”their architecture of which were embedded boron atom in their scaffold or skeleton. These boron tracedrugs could be detected whenever and wherever you need to access in their lifetime. We called them“honnête homme”drugs. Also utilizing this specific property of boron tracedrugs, we suggested the neutron dynamic therapy(NDT).
Journal Title
四国医学雑誌
ISSN
00373699
NCID
AN00102041
Publisher
徳島医学会
Volume
67
Issue
1-2
Start Page
7
End Page
14
Sort Key
7
Published Date
2011-04-25
EDB ID
FullText File
language
jpn
TextVersion
Publisher
departments
Bioscience and Bioindustry