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ID 110345
タイトルヨミ
テイサンソ ヒョウテキ ヤクザイ ノ メディシナル ブリコラージュ ト ジセダイ イヤクヒン ボロン トレースドラッグ ノ ソウセイ
タイトル別表記
Medicinal bricolage design of hypoxia-targeting drugs and invention of boron tracedrugs as next-generation universal drugs
著者
堀, 均 徳島大学大学院ソシオテクノサイエンス研究部ライフシステム部門 徳島大学 教育研究者総覧 KAKEN研究者をさがす
宇都, 義浩 徳島大学大学院ソシオテクノサイエンス研究部ライフシステム部門 徳島大学 教育研究者総覧 KAKEN研究者をさがす
中田, 栄司 徳島大学大学院ソシオテクノサイエンス研究部ライフシステム部門|京都大学エネルギー理工学研究所エネルギー利用過程研究部門
キーワード
hypoxia-targeting antitumor drug
hypoxic cell radiosensitizer
hypoxic cytotoxin
boron tracedrug
neutron dynamic therapy
資料タイプ
学術雑誌論文
抄録
Hypoxia is now considered a fundamentally important characteristic of the tumor microenvironment. A discovery of the hypoxia inducible factor(HIF)has led to a rapidly increasing understanding of the molecular mechanisms involved in tumor hypoxia. This in turn has led to the current extensive interest in the signal molecules related to tumor hypoxia as potential molecular targets for cancer therapeutics. In this paper we give a medicinal bricolage overview of recent advances in hypoxia-targeting drugs research. These hypoxia-targeting drugs include antiangiogenic- and sugar-hybrid-hypoxic cell radiosensitizers and hypoxic cytotoxins, hypoxia-targeting boron neutron capture therapy(BNCT)drugs. The evaluation of ADME-tox and pharmacokinetic properties of drugs are extremely important and essential in their discovery process and their lifetime. Traditionally, as well known traceable drugs, their radiolabeled compounds have been studied for their purposes. However, there are some inherent problems such as their half-life and regulation of experimental facilities. For the purpose of overcoming these problems and creating drugs with functions required for systems biology or emerging physiology, we designed, as a traceable nextgeneration drug model, wholly innovative drugs named“boron tracedrug,”their architecture of which were embedded boron atom in their scaffold or skeleton. These boron tracedrugs could be detected whenever and wherever you need to access in their lifetime. We called them“honnête homme”drugs. Also utilizing this specific property of boron tracedrugs, we suggested the neutron dynamic therapy(NDT).
掲載誌名
四国医学雑誌
ISSN
00373699
cat書誌ID
AN00102041
出版者
徳島医学会
67
1-2
開始ページ
7
終了ページ
14
並び順
7
発行日
2011-04-25
EDB ID
フルテキストファイル
言語
jpn
著者版フラグ
出版社版
部局
生物資源系