ID | 110345 |
タイトルヨミ | テイサンソ ヒョウテキ ヤクザイ ノ メディシナル ブリコラージュ ト ジセダイ イヤクヒン ボロン トレースドラッグ ノ ソウセイ
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タイトル別表記 | Medicinal bricolage design of hypoxia-targeting drugs and invention of boron tracedrugs as next-generation universal drugs
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著者 |
中田, 栄司
徳島大学大学院ソシオテクノサイエンス研究部ライフシステム部門|京都大学エネルギー理工学研究所エネルギー利用過程研究部門
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キーワード | hypoxia-targeting antitumor drug
hypoxic cell radiosensitizer
hypoxic cytotoxin
boron tracedrug
neutron dynamic therapy
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資料タイプ |
学術雑誌論文
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抄録 | Hypoxia is now considered a fundamentally important characteristic of the tumor microenvironment. A discovery of the hypoxia inducible factor(HIF)has led to a rapidly increasing understanding of the molecular mechanisms involved in tumor hypoxia. This in turn has led to the current extensive interest in the signal molecules related to tumor hypoxia as potential molecular targets for cancer therapeutics. In this paper we give a medicinal bricolage overview of recent advances in hypoxia-targeting drugs research. These hypoxia-targeting drugs include antiangiogenic- and sugar-hybrid-hypoxic cell radiosensitizers and hypoxic cytotoxins, hypoxia-targeting boron neutron capture therapy(BNCT)drugs. The evaluation of ADME-tox and pharmacokinetic properties of drugs are extremely important and essential in their discovery process and their lifetime. Traditionally, as well known traceable drugs, their radiolabeled compounds have been studied for their purposes. However, there are some inherent problems such as their half-life and regulation of experimental facilities. For the purpose of overcoming these problems and creating drugs with functions required for systems biology or emerging physiology, we designed, as a traceable nextgeneration drug model, wholly innovative drugs named“boron tracedrug,”their architecture of which were embedded boron atom in their scaffold or skeleton. These boron tracedrugs could be detected whenever and wherever you need to access in their lifetime. We called them“honnête homme”drugs. Also utilizing this specific property of boron tracedrugs, we suggested the neutron dynamic therapy(NDT).
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掲載誌名 |
四国医学雑誌
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ISSN | 00373699
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cat書誌ID | AN00102041
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出版者 | 徳島医学会
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巻 | 67
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号 | 1-2
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開始ページ | 7
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終了ページ | 14
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並び順 | 7
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発行日 | 2011-04-25
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EDB ID | |
フルテキストファイル | |
言語 |
jpn
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著者版フラグ |
出版社版
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部局 |
生物資源系
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