ID 110347
Title Transcription
ジンゾウ ニオケル サンソ タイシャ イジョウ ト シンキ テイサンソ チリョウ ターゲット ノ タンサク
Title Alternative
Abnormal oxygen metabolism of the kidney and identification of novel therapeutic targets against hypoxia
Author
Nangaku, Masaomi Division of Nephrology and Endocrinology, University of Tokyo School of Medicine
Keywords
hypoxia
oxygen
HIF
ischemia
chronic kidney disease
Content Type
Journal Article
Description
Chronic hypoxia in the tubulointerstitium serves as a final common pathway to end stage kidney disease in a variety of kidney diseases. Oxygen demand of the kidney is large, and the oxygen uptake efficiency of the kidney is relatively low due to arterio-venous oxygen shunt. Thus, the kidney can be hypoxic easily. In diseased kidneys, induction of hypoxia of the kidney is multifactorial. These factors include reduction of peritubular capillary blood flow due to activation of the renin-angiotensin system, increased oxygen consumption by tubular cells due to uremia, and renal anemia. Cells are endowed with the defensive mechanism against hypoxia, and hypoxia-inducible factor(HIF)serves as a master gene switch of various adaptive mechanisms, and activation of HIF induces a number of defensive responses in a coordinated manner. Many studies showed protective effects of HIF activation in experimental models of kidney disorders, and we are now performing detailed analysis of responses induced by HIF activation utilizing ChIP-Seq.
Journal Title
四国医学雑誌
ISSN
00373699
NCID
AN00102041
Publisher
徳島医学会
Volume
67
Issue
1-2
Start Page
21
End Page
24
Sort Key
21
Published Date
2011-04-25
FullText File
language
jpn
TextVersion
Publisher