ID 110347
タイトルヨミ
ジンゾウ ニオケル サンソ タイシャ イジョウ ト シンキ テイサンソ チリョウ ターゲット ノ タンサク
タイトル別表記
Abnormal oxygen metabolism of the kidney and identification of novel therapeutic targets against hypoxia
著者
南学, 正臣 東京大学医学部附属病院腎臓内分泌内科
キーワード
hypoxia
oxygen
HIF
ischemia
chronic kidney disease
資料タイプ
学術雑誌論文
抄録
Chronic hypoxia in the tubulointerstitium serves as a final common pathway to end stage kidney disease in a variety of kidney diseases. Oxygen demand of the kidney is large, and the oxygen uptake efficiency of the kidney is relatively low due to arterio-venous oxygen shunt. Thus, the kidney can be hypoxic easily. In diseased kidneys, induction of hypoxia of the kidney is multifactorial. These factors include reduction of peritubular capillary blood flow due to activation of the renin-angiotensin system, increased oxygen consumption by tubular cells due to uremia, and renal anemia. Cells are endowed with the defensive mechanism against hypoxia, and hypoxia-inducible factor(HIF)serves as a master gene switch of various adaptive mechanisms, and activation of HIF induces a number of defensive responses in a coordinated manner. Many studies showed protective effects of HIF activation in experimental models of kidney disorders, and we are now performing detailed analysis of responses induced by HIF activation utilizing ChIP-Seq.
掲載誌名
四国医学雑誌
ISSN
00373699
cat書誌ID
AN00102041
出版者
徳島医学会
67
1-2
開始ページ
21
終了ページ
24
並び順
21
発行日
2011-04-25
フルテキストファイル
言語
jpn
著者版フラグ
出版社版