ID 110358
Title Transcription
ショウニ ノ タンカン カクチョウガタ スイ タンカン ゴウリュウ イジョウ セツジョレイ ニ ハツガン カンレン イデンシ HDAC ガ コウハツゲン シテイタ 1レイ
Title Alternative
Infant biliary dilatation type pancreaticobiliary maljunction with the high expression of histone deacetylase : report of a case
Author
Mori, Hiroki Department of Digestive Surgery and Transplantation, Tokushima University Hospital Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Ishibashi, Hiroki Department of Digestive Surgery and Transplantation, Tokushima University Hospital Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Kuyama, Hisako Department of Digestive Surgery and Transplantation, Tokushima University Hospital
Imura, Satoru Department of Digestive Surgery and Transplantation, Tokushima University Hospital Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Morine, Yuji Department of Digestive Surgery and Transplantation, Tokushima University Hospital Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Sato, Hirohiko Department of Digestive Surgery and Transplantation, Tokushima University Hospital
Utsunomiya, Tohru Department of Digestive Surgery and Transplantation, Tokushima University Hospital
Shimada, Mitsuo Department of Digestive Surgery and Transplantation, Tokushima University Hospital Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Keywords
pancreaticobiliary maljunction
biliary dilatation
biliary tract cancer
histone deacetylase
Content Type
Journal Article
Description
Pancreaticobiliary maljunction(PBM)is the congenital malformation that the junction of the pancreatic and bile ducts is located outside of the duodenal wall anatomically, so sphincter function preventing to mix the bile and pancreatic juice does not act. In PBM, the mutual reflux of bile and pancreatic juice induces various diseases and becomes the cause of biliary tract cancer generation. PBM is divided into PBM with the biliary dilatation and PBM without the biliary dilatation. From the perspective of carcinogenesis, surgery to separate the pancreatic juice and bile by excision of extrahepatic biliary tract and hepaticojejunostomy is commonly performed in the former, the treatment of the latter is controversial, for instance ; the only cholecystectomy should be performed and excision of extrahepatic biliary tract is unnecessary or excision of extrahepatic biliary tract and hepaticojejunostomy should be done. In addition, histone acetylation and histone deacetylation is one of the important regulatory mechanism of gene transcription, the error of the balance between histone acetyltransferase(HAT)and histone deacetylase(HDAC)leads to carcinogenesis. In other words, HDAC has a carcinogenic potential. Overexpression of HDAC was found in the both resected gallbladder and bile duct mucosa of infant PBM patient with the biliary dilatation performed the excision of extrahepatic biliary tract and hepaticojejunostomy in our department. Appropriate treatment for PBM has not been established yet, but even infant case with PBM has carcinogenesis potential just like this case. In conclusion, further accumulation of cases including PBM without the biliary dilatation was thought to be essential though the excision of extrahepatic biliary tract and hepaticojejunostomy still seems to be required for infant PBM patient with the biliary dilatation.
Journal Title
四国医学雑誌
ISSN
00373699
NCID
AN00102041
Publisher
徳島医学会
Volume
67
Issue
1-2
Start Page
77
End Page
82
Sort Key
77
Published Date
2011-04-25
EDB ID
FullText File
language
jpn
TextVersion
Publisher
departments
University Hospital
Medical Sciences