ID 110358
タイトルヨミ
ショウニ ノ タンカン カクチョウガタ スイ タンカン ゴウリュウ イジョウ セツジョレイ ニ ハツガン カンレン イデンシ HDAC ガ コウハツゲン シテイタ 1レイ
タイトル別表記
Infant biliary dilatation type pancreaticobiliary maljunction with the high expression of histone deacetylase : report of a case
著者
久山, 寿子 徳島大学病院消化器・移植外科
佐藤, 宏彦 徳島大学病院消化器・移植外科
宇都宮, 徹 徳島大学病院消化器・移植外科
キーワード
pancreaticobiliary maljunction
biliary dilatation
biliary tract cancer
histone deacetylase
資料タイプ
学術雑誌論文
抄録
Pancreaticobiliary maljunction(PBM)is the congenital malformation that the junction of the pancreatic and bile ducts is located outside of the duodenal wall anatomically, so sphincter function preventing to mix the bile and pancreatic juice does not act. In PBM, the mutual reflux of bile and pancreatic juice induces various diseases and becomes the cause of biliary tract cancer generation. PBM is divided into PBM with the biliary dilatation and PBM without the biliary dilatation. From the perspective of carcinogenesis, surgery to separate the pancreatic juice and bile by excision of extrahepatic biliary tract and hepaticojejunostomy is commonly performed in the former, the treatment of the latter is controversial, for instance ; the only cholecystectomy should be performed and excision of extrahepatic biliary tract is unnecessary or excision of extrahepatic biliary tract and hepaticojejunostomy should be done. In addition, histone acetylation and histone deacetylation is one of the important regulatory mechanism of gene transcription, the error of the balance between histone acetyltransferase(HAT)and histone deacetylase(HDAC)leads to carcinogenesis. In other words, HDAC has a carcinogenic potential. Overexpression of HDAC was found in the both resected gallbladder and bile duct mucosa of infant PBM patient with the biliary dilatation performed the excision of extrahepatic biliary tract and hepaticojejunostomy in our department. Appropriate treatment for PBM has not been established yet, but even infant case with PBM has carcinogenesis potential just like this case. In conclusion, further accumulation of cases including PBM without the biliary dilatation was thought to be essential though the excision of extrahepatic biliary tract and hepaticojejunostomy still seems to be required for infant PBM patient with the biliary dilatation.
掲載誌名
四国医学雑誌
ISSN
00373699
cat書誌ID
AN00102041
出版者
徳島医学会
67
1-2
開始ページ
77
終了ページ
82
並び順
77
発行日
2011-04-25
EDB ID
250867
フルテキストファイル
言語
jpn
著者版フラグ
出版社版
部局
病院
医学系