ID 110373
Title Transcription
チョクセツ サヨウガタ コウウイルスヤク DAAs ニヨル Cガタ マンセイ カンシッカン シンリョウ
Title Alternative
Antiviral therapy for chronic hepatitis C by means of direct acting anti-viral drugs
Author
Tamori, Akihiro Department of Hepatology, Osaka City University Graduate School of Medicine
Keywords
Chronic liver diseases
DAAs
HCV
interferon free therapy
Content Type
Journal Article
Description
Hepatitis C virus(HCV)infection is a major worldwide health problem. Chronic infection induces continuous inflammation in the liver, progression of hepatic fibrosis, eventual cirrhosis, and possible hepatocellular carcinoma. Eradication of the virus is one of the most important treatment aims. A number of promising new direct-acting antivirals(DAAs)have been developed over the past 10 years. Due to their increased efficacy, safety, and tolerability, interferon-free oral therapies with DAAs have been approved for patients with HCV, including those with cirrhosis. This review introduces the characteristics and results of recent clinical trials of several DAAs : NS3/4 A protease inhibitors, NS5A inhibitors, and NS5B inhibitors. DAA treatment failure and prognosis after DAA therapy are also discussed.
Journal Title
四国医学雑誌
ISSN
00373699
NCID
AN00102041
Publisher
徳島医学会
Volume
72
Issue
1-2
Start Page
9
End Page
12
Sort Key
9
Published Date
2016-04-25
FullText File
language
jpn
TextVersion
Publisher