ID 110432
Title Transcription
サンカ ストレス ト ショクヒン コウサンカ ブッシツ
Title Alternative
Function of dietary antioxidants on the protection against oxidative stress
Author
Terao, Junji Department of Nutrition, The University of Tokushima School of Medicine Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Keywords
Antioxidants
flavonoids
lipid peroxidation
glucuronyl conjugates
quercetin
Content Type
Journal Article
Description
Daily foods contain a variety of minor components which possess antioxidative activity, such as vitamin E and vitamin C. On the other hand, it has been well known that reactive oxygen species (ROS) generating in the body cause oxidative damages in the tissues and fluids, resulting in the generation and progress of life style-related diseases. Therefore, it should be expected that dietary antioxidants are well introduced to individual food-style from the viewpoint of disease prevention and health promotion. However, there are two important subjects to be clarified, that is, the mechanism by which they exert the antioxidant activity in vivo, and the site at which they act as antioxidants in vivo. We are interested in common components present in foodstuffs, in particular, carotenoids, flavonoids and phytic acid, and are challenging to solve these subjects by use of carotenoids and flavonoids. Here we will discuss the result of our recent studies on dietary flavonoids. We have claimed that flavonoids are interfacial antioxidants whose activities appear at the interface between lipid-phase and water-phase. Nevertheless, little is known on the absorption and metabolism of flavonoids from diet. We recently investigated the absorption and metabolic pathway of quercetin, a representative flavonoid in plant foods, using rats, humans and cultured cell derived from human digestive tract. The result shows that a part of quercetin is absorbed from digestive tract and exclusively accumulates as conjugated metabolites in blood plasma. The antioxidative activity of quercetin exhibited in blood plasma is likely to be originated from conjugated metabolites. It is therefore implied that metabolic products largely contribute to the physiological function of flavonoids, when flavonoids are ingested from daily foods.
Journal Title
四国医学雑誌
ISSN
00373699
NCID
AN00102041
Publisher
徳島医学会
Volume
56
Issue
1
Start Page
13
End Page
18
Sort Key
13
Published Date
2000-02-25
FullText File
language
jpn
TextVersion
Publisher
departments
Medical Sciences