ID 110432
タイトルヨミ
サンカ ストレス ト ショクヒン コウサンカ ブッシツ
タイトル別表記
Function of dietary antioxidants on the protection against oxidative stress
著者
寺尾, 純二 徳島大学医学部栄養学科食品学講座 徳島大学 教育研究者総覧 KAKEN研究者をさがす
キーワード
Antioxidants
flavonoids
lipid peroxidation
glucuronyl conjugates
quercetin
資料タイプ
学術雑誌論文
抄録
Daily foods contain a variety of minor components which possess antioxidative activity, such as vitamin E and vitamin C. On the other hand, it has been well known that reactive oxygen species (ROS) generating in the body cause oxidative damages in the tissues and fluids, resulting in the generation and progress of life style-related diseases. Therefore, it should be expected that dietary antioxidants are well introduced to individual food-style from the viewpoint of disease prevention and health promotion. However, there are two important subjects to be clarified, that is, the mechanism by which they exert the antioxidant activity in vivo, and the site at which they act as antioxidants in vivo. We are interested in common components present in foodstuffs, in particular, carotenoids, flavonoids and phytic acid, and are challenging to solve these subjects by use of carotenoids and flavonoids. Here we will discuss the result of our recent studies on dietary flavonoids. We have claimed that flavonoids are interfacial antioxidants whose activities appear at the interface between lipid-phase and water-phase. Nevertheless, little is known on the absorption and metabolism of flavonoids from diet. We recently investigated the absorption and metabolic pathway of quercetin, a representative flavonoid in plant foods, using rats, humans and cultured cell derived from human digestive tract. The result shows that a part of quercetin is absorbed from digestive tract and exclusively accumulates as conjugated metabolites in blood plasma. The antioxidative activity of quercetin exhibited in blood plasma is likely to be originated from conjugated metabolites. It is therefore implied that metabolic products largely contribute to the physiological function of flavonoids, when flavonoids are ingested from daily foods.
掲載誌名
四国医学雑誌
ISSN
00373699
cat書誌ID
AN00102041
出版者
徳島医学会
56
1
開始ページ
13
終了ページ
18
並び順
13
発行日
2000-02-25
フルテキストファイル
言語
jpn
著者版フラグ
出版社版
部局
医学系