ID 110435
Title Transcription
メサンギウム サイボウ ゾウショク ニカンスル アラタナ セイギョ インシ ト ビョウヘン ヨクシ ニカンスル ケンキュウ
Title Alternative
A novel mechanism of growth regulation on mesangial proliferation
Author
Doi, Toshio Department of Laboratory Medicine, The University of Tokushima School of Medicine Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Keywords
Gas 6
22-oxa-calcitriol
mesangial proliferation
Warfarin
vitamin K
Content Type
Journal Article
Description
Mesangial proliferation is a common feature of many glomerular diseases, therefore, understanding the regulatory mechanism is important for the treatment of glomerular diseases. The present study showed growth arrest gene-6 (Gas6) is a new autocrine growth factor of mesangial cells and warfarin inhibited mesangial proliferation by inhibiting γ-carboxylation of Gas 6 in vitro and in vivo. We also found vitamin D anlog (22-oxa-calcitriol) is a new growth regulator for mesangial cells in vivo. These results indicate that these compounds have considerable potential for use as therapeutic strategy in the treatment of progressive glomerular disease.
Journal Title
四国医学雑誌
ISSN
00373699
NCID
AN00102041
Publisher
徳島医学会
Volume
56
Issue
1
Start Page
25
End Page
28
Sort Key
25
Published Date
2000-02-25
FullText File
language
jpn
TextVersion
Publisher
departments
Medical Sciences