ID 110461
Title Transcription
イデンシ シンダン ト ソノ モンダイテン
Title Alternative
DNA diagnosis : advantages and weak points
Author
Ito, Michinori Department of Pediatrics, The University of Tokushima School of Medicine
Keywords
DNA diagnosis
advantage
weak point
Content Type
Journal Article
Description
In recent years, many disease-related genes has been found with the development of molecular biological technique and molecular genetical analyses in patients with these diseases have been performed in clinical medicine. DNA diagnosis, diagnosis by detection of the mutation in disease-related genes, has a lot of advantages compared to usual diagnostic method. However, DNA diagnosis still has several weak points in clinical medicine. The first weak point is that we can not diagnose the patient as normal even when no mutation is found by DNA analysis. The second weak point is that functional analysis of the gene product,which is hard in clinical medicine, is necessary to confirm the mutation as the pathogenic mutation when the new mutation is found in the patient. Finally, it is also the problem that the sufficient supporting system for the patients after DNA diagnosis is not established in Japan. Then, it is important that not only advantages but also these weak points are fully considered before DNA diagnosis.
Journal Title
四国医学雑誌
ISSN
00373699
NCID
AN00102041
Publisher
徳島医学会
Volume
56
Issue
5
Start Page
160
End Page
164
Sort Key
160
Published Date
2000-10-25
FullText File
language
jpn
TextVersion
Publisher