ID 110564
Title Transcription
ナゼ アレルギー シッカン ワ ゾウカ シテ イルノカ : メンエキガク ノ タチバ ヨリ
Title Alternative
What increases allergic diseases in recent years? : from the view of immunology
Author
Tsukumo, Shin-ichi Department of Immunology amp Parasitology, The University of Tokushima School of Medicine Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Hisaeda, Hajime Department of Immunology amp Parasitology, The University of Tokushima School of Medicine
Yasutomo, Koji Department of Immunology amp Parasitology, The University of Tokushima School of Medicine Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Keywords
type I allergy
IgE
Th2
mast cell
infection
Content Type
Journal Article
Description
Type I allergic diseases, such as rhinitis, pollinosis and bronchial asthma, are mediated by Th2-type helper T cell induction, specific IgE antibody production and mast cell activation. Increases of these allergic diseases in recent years might be caused by skewed differentiation of T cells toward Th2 cells by some environmental factors including diesel exhaust particles and decreases of virus and bacteria infection in childhood. The decrease of parasite infection is also thought to affect the susceptibility against allergic diseases by eliciting polyclonal IgE production that suppresses mast cell activation. Important clues for prevention and therapy of the allergic diseases would be derived from further investigations of the relationship between the diseases and these environmental factors.
Journal Title
四国医学雑誌
ISSN
00373699
NCID
AN00102041
Publisher
徳島医学会
Volume
58
Issue
6
Start Page
265
End Page
266
Sort Key
265
Published Date
2002-12-25
FullText File
language
jpn
TextVersion
Publisher
departments
Medical Sciences