ID 110572
Title Transcription
ムジュウリョク ニオケル コツタイシャ ト コツソショウショウ
Title Alternative
Bone metabolic changes and osteoporosis caused by microgravity and mechanical unloading
Author
Inoue, Daisuke Department of Medicine and Bioregulatory Sciences, The University of Tokushima Graduate School of Medicine
Keywords
mechanical loading
immobilization osteoporosis
uncoupling
bisphosphonate
Content Type
Journal Article
Description
Mechanical unloading causes rapid and severe bone loss in astronauts subjected to microgravity or bed-ridden patients, which is designated as immobilization osteoporosis. Metabolic changes in unloaded bone are characterized by “uncoupling” which involves both enhanced bone resorption and impaired bone formation. Although it has long been well recognized and extensively studied, the pathophysiology of immobilization osteoporosis is not yet fully understood. This overview will focus on our recent understanding of the pathophysiology of immobilization osteoporosis and the mechanism by which mechanical loading affects bone metabolism. Finally, the current therapeutic approaches including anti-resorptive bisphosphonates as well as future aspects in the treatment of immobilization osteoporosis will be discussed.
Journal Title
四国医学雑誌
ISSN
00373699
NCID
AN00102041
Publisher
徳島医学会
Volume
58
Issue
6
Start Page
296
End Page
301
Sort Key
296
Published Date
2002-12-25
FullText File
language
jpn
TextVersion
Publisher