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ID 110572
タイトルヨミ
ムジュウリョク ニオケル コツタイシャ ト コツソショウショウ
タイトル別表記
Bone metabolic changes and osteoporosis caused by microgravity and mechanical unloading
著者
井上, 大輔 徳島大学大学院医学研究科生体制御医学講座生体情報内科学分野
キーワード
mechanical loading
immobilization osteoporosis
uncoupling
bisphosphonate
資料タイプ
学術雑誌論文
抄録
Mechanical unloading causes rapid and severe bone loss in astronauts subjected to microgravity or bed-ridden patients, which is designated as immobilization osteoporosis. Metabolic changes in unloaded bone are characterized by “uncoupling” which involves both enhanced bone resorption and impaired bone formation. Although it has long been well recognized and extensively studied, the pathophysiology of immobilization osteoporosis is not yet fully understood. This overview will focus on our recent understanding of the pathophysiology of immobilization osteoporosis and the mechanism by which mechanical loading affects bone metabolism. Finally, the current therapeutic approaches including anti-resorptive bisphosphonates as well as future aspects in the treatment of immobilization osteoporosis will be discussed.
掲載誌名
四国医学雑誌
ISSN
00373699
cat書誌ID
AN00102041
出版者
徳島医学会
58
6
開始ページ
296
終了ページ
301
並び順
296
発行日
2002-12-25
フルテキストファイル
言語
jpn
著者版フラグ
出版社版