ID 110617
Title Transcription
シボウ サイボウ ノ カガク
Title Alternative
Science of adipose tissue
Author
Nakaya, Yutaka Department of Nutrition, The University of Tokushima School of Medicine Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Matsushima, Rie Department of Nutrition, The University of Tokushima School of Medicine
Morishima, Masaki Department of Nutrition, The University of Tokushima School of Medicine Tokushima University Educator and Researcher Directory
Harada, Nagakatu Department of Nutrition, The University of Tokushima School of Medicine KAKEN Search Researchers
Keywords
adipocytokines
adiponectin
fat tissue
tumor necrosis factor
plasminogen activator inhibitor-1
atherosclerosis
Content Type
Journal Article
Description
Adipose tissue secretes a variety of bioactive molecules (adipocytokines) that directlycontribute to the development of life-style related diseases, such as diabetes, hypertension,and cardiovascular diseases. TNF-α is a well - known inhibitor of insulin signaling and PAI(plasminogen activator inhibitor) - 1 contributes to thrombus formation. Adiponectin has anaction both insulin sensitivity and anti - atherogenic action. Interestingly, low plasmaadiponectin concentrations were observed in patients with obesity, coronary artery disease(CAD), and type 2 diabetes. Adiponectin from the plasma adhered to the injured arteryand suppressed the endothelial expression of adhesion molecules, the proliferation ofvascular smooth muscle cells, and the transformation of macrophage to foam cells. Thesefindings support that accumulation of fat produces not only insulin resistance but alsoatherosclrosis in obese subjects.
Journal Title
四国医学雑誌
ISSN
00373699
NCID
AN00102041
Publisher
徳島医学会
Volume
59
Issue
4-5
Start Page
211
End Page
213
Sort Key
211
Published Date
2003-10-25
FullText File
language
jpn
TextVersion
Publisher
departments
University Hospital
Medical Sciences