ID 110619
Title Transcription
Brugada ショウコウグン ト ソノ トリアツカイ
Title Alternative
The Brugada syndrome and its treatment
Author
Saitoh, Ken Department of Functional Laboratory Science, School of Health Sciences, The University of Tokushima Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Nomura, Masahiro Department of Digestion and Cardiovascular Medicine, The University of Tokushima School of Medicine
Keywords
Brugada syndrome
Brugada-type ECG
autonomic imbalance
idiopathic VF
sudden cardiac death
Content Type
Journal Article
Description
In 1992, Brugada brothers reported 8 patients with aborted sudden death withoutorganic heart disease and exhibiting a characteristic ECG pattern of right bundle branch block(RBBB) and ST-segment elevation in right precordial leads (V1-V3). The syndrome is afamilial disease and most frequently diagnosed in middle-aged men of Asian origin. Thearrhythmic events such as polymorphic ventricular tachycardia (VT) or ventricular fibrillation(VF) are frequently generated during sleep. The Brugada syndrome has been linked tomutations in SCN5A, the gene encording for the -subunit of the sodium channel. Sodiumchannel blockers (class IA and IC) identify the risk of sudden death in patients with thesyndrome. Implantation of ICD is the only effective treatment of the VF for Brugadasyndrome. The Brugada-type ECG in annual health examinations for adult citizens is not avery rare condition in Japan. Although it is reported that the mortality of subjects with theBrugada-type ECG in a community-based population is low compared with the mortalityseen in a hospital-based study, there is also a report of the example of death in asymptomaticcases and the further study about a prognosis of Brugada syndrome is required.
Journal Title
四国医学雑誌
ISSN
00373699
NCID
AN00102041
Publisher
徳島医学会
Volume
59
Issue
4-5
Start Page
220
End Page
227
Sort Key
220
Published Date
2003-10-25
EDB ID
FullText File
language
jpn
TextVersion
Publisher
departments
Medical Sciences