ID 110619
タイトルヨミ
Brugada ショウコウグン ト ソノ トリアツカイ
タイトル別表記
The Brugada syndrome and its treatment
著者
齋藤, 憲 徳島大学医学部保健学科機能系検査学講座 徳島大学 教育研究者総覧 KAKEN研究者をさがす
野村, 昌弘 徳島大学医学部病態予防医学講座臓器病態治療医学分野
キーワード
Brugada syndrome
Brugada-type ECG
autonomic imbalance
idiopathic VF
sudden cardiac death
資料タイプ
学術雑誌論文
抄録
In 1992, Brugada brothers reported 8 patients with aborted sudden death withoutorganic heart disease and exhibiting a characteristic ECG pattern of right bundle branch block(RBBB) and ST-segment elevation in right precordial leads (V1-V3). The syndrome is afamilial disease and most frequently diagnosed in middle-aged men of Asian origin. Thearrhythmic events such as polymorphic ventricular tachycardia (VT) or ventricular fibrillation(VF) are frequently generated during sleep. The Brugada syndrome has been linked tomutations in SCN5A, the gene encording for the -subunit of the sodium channel. Sodiumchannel blockers (class IA and IC) identify the risk of sudden death in patients with thesyndrome. Implantation of ICD is the only effective treatment of the VF for Brugadasyndrome. The Brugada-type ECG in annual health examinations for adult citizens is not avery rare condition in Japan. Although it is reported that the mortality of subjects with theBrugada-type ECG in a community-based population is low compared with the mortalityseen in a hospital-based study, there is also a report of the example of death in asymptomaticcases and the further study about a prognosis of Brugada syndrome is required.
掲載誌名
四国医学雑誌
ISSN
00373699
cat書誌ID
AN00102041
出版者
徳島医学会
59
4-5
開始ページ
220
終了ページ
227
並び順
220
発行日
2003-10-25
EDB ID
88282
フルテキストファイル
言語
jpn
著者版フラグ
出版社版
部局
医学系