ID 110642
Author
Sun, Xue-Zhi Environmental and Toxicological Sciences Research Group, National Institute of Radiological Sciences
Takahashi, Sentaro Environmental and Toxicological Sciences Research Group, National Institute of Radiological Sciences
Cui, Chun Department of Anatomy and Developmental Neurobiology, The University of Tokushima School of Medicine
Zhang, Rui Environmental and Toxicological Sciences Research Group, National Institute of Radiological Sciences
Sakata-Haga, Hiromi Department of Anatomy and Developmental Neurobiology, The University of Tokushima School of Medicine
Sawada, Kazuhiko Department of Anatomy and Developmental Neurobiology, The University of Tokushima School of Medicine
Fukui, Yoshihiro Department of Anatomy and Developmental Neurobiology, The University of Tokushima School of Medicine Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Keywords
cerebrum
ectopia
migration disorder
radial glia
Content Type
Journal Article
Description
Neuronal migration is the critical cellular process which initiates histogenesis of cerebral cortex. Migration involves a series of complex cell interactions and transformation. After completing their final mitosis, neurons migrate from the ventricular zone into the cortical plate, and then establish neuronal lamina and settle onto the outermost layer, forming an “inside-out” gradient of maturation. This process is guided by radial glial fibers, requires proper receptors, ligands, other unknown extracellular factors, and local signaling to stop neuronal migration. This process is also highly sensitive to various physical, chemical and biological agents as well as to genetic mutations. Any disturbance of the normal process may result in neuronal migration disorder. Such neuronal migration disorder is believed as major cause of both gross brain malformation and more special cerebral structural and functional abnormalities in experimental animals and in humans. An increasing number of instructive studies on experimental models and several genetic model systems of neuronal migration disorder have established the foundation of cortex formation and provided deeper insights into the genetic and molecular mechanisms underlying normal and abnormal neuronal migration.
Journal Title
The journal of medical investigation : JMI
ISSN
13431420
NCID
AA11166929
Volume
49
Issue
3-4
Start Page
97
End Page
110
Sort Key
97
Published Date
2002
EDB ID
FullText File
language
eng
TextVersion
Publisher
departments
Medical Sciences