ID 110642
著者
Sun, Xue-Zhi Environmental and Toxicological Sciences Research Group, National Institute of Radiological Sciences
タカハシ, センタロウ Environmental and Toxicological Sciences Research Group, National Institute of Radiological Sciences
Cui, Chun Department of Anatomy and Developmental Neurobiology, The University of Tokushima School of Medicine
Zhang, Rui Environmental and Toxicological Sciences Research Group, National Institute of Radiological Sciences
坂田, ひろみ Department of Anatomy and Developmental Neurobiology, The University of Tokushima School of Medicine
澤田, 和彦 Department of Anatomy and Developmental Neurobiology, The University of Tokushima School of Medicine
福井, 義浩 Department of Anatomy and Developmental Neurobiology, The University of Tokushima School of Medicine 徳島大学 教育研究者総覧 KAKEN研究者をさがす
キーワード
cerebrum
ectopia
migration disorder
radial glia
資料タイプ
学術雑誌論文
抄録
Neuronal migration is the critical cellular process which initiates histogenesis of cerebral cortex. Migration involves a series of complex cell interactions and transformation. After completing their final mitosis, neurons migrate from the ventricular zone into the cortical plate, and then establish neuronal lamina and settle onto the outermost layer, forming an “inside-out” gradient of maturation. This process is guided by radial glial fibers, requires proper receptors, ligands, other unknown extracellular factors, and local signaling to stop neuronal migration. This process is also highly sensitive to various physical, chemical and biological agents as well as to genetic mutations. Any disturbance of the normal process may result in neuronal migration disorder. Such neuronal migration disorder is believed as major cause of both gross brain malformation and more special cerebral structural and functional abnormalities in experimental animals and in humans. An increasing number of instructive studies on experimental models and several genetic model systems of neuronal migration disorder have established the foundation of cortex formation and provided deeper insights into the genetic and molecular mechanisms underlying normal and abnormal neuronal migration.
掲載誌名
The journal of medical investigation : JMI
ISSN
13431420
cat書誌ID
AA11166929
49
3-4
開始ページ
97
終了ページ
110
並び順
97
発行日
2002
EDB ID
130666
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
医学系