ID 110662
Author
Ye, Qing First Department of Pathology, University Hospital, The University of Tokushima School of Medicine
Ohsaki, Katsuichiro Division of Clinical Otology, University Hospital, The University of Tokushima School of Medicine
Ii, Kunio First Department of Pathology, University Hospital, The University of Tokushima School of Medicine
Li, Dong-jun Division of Clinical Otology, University Hospital, The University of Tokushima School of Medicine
Matsuoka, Hiroshi Division of Clinical Otology, University Hospital, The University of Tokushima School of Medicine
Tenshin, Satoru Department of Orthodontics, The University of Tokushima School of Dentistry
Yamamoto, Teruko Department of Orthodontics, Okayama University Dental School
Keywords
aluminum oxide ceramics
histology
cell count
biocompatible materials
rats
Content Type
Journal Article
Description
The discs of synthetic auditory ossicle (Bioceram®), which are composed of aluminium oxide (Al2O3), were implanted subcutaneously in the interscapular region of 16 rats. The implanted specimens were removed at 1, 3, 7 and 14 days after implantation. The decalcified 6 μm thick sections were stained with H.E. and cell types around the implants were counted microscopically. We found that an acute inflammatory reaction occurred at one day, in which macrophages and neutrophils predominated, and almost disappeared at about 7 days after implantation. Fibrosis began to be observed at 3 days. During this early stage, foreign body giant cells were found in only one specimen at 3 days. These findings, in comparison with those in the controls, showed that the chemical irritation of Bioceram® to the subcutaneous tissue is slight, although the physical and/or chemical irritation of Bioceram® lasts continuously and induces fibrosis around the bioimplant. The results so far suggest that Bioceram® seems to be a satisfactorily biocompatible material, at least within the extent of 2 weeks.
Journal Title
The journal of medical investigation : JMI
ISSN
13431420
NCID
AA11166929
Volume
44
Issue
3-4
Start Page
173
End Page
177
Sort Key
173
Published Date
1998
FullText File
language
eng
TextVersion
Publisher