ID 110662
著者
Ye, Qing First Department of Pathology, University Hospital, The University of Tokushima School of Medicine
オオサキ, カツイチロウ Division of Clinical Otology, University Hospital, The University of Tokushima School of Medicine
イイ, クニオ First Department of Pathology, University Hospital, The University of Tokushima School of Medicine
Li, Dong-jun Division of Clinical Otology, University Hospital, The University of Tokushima School of Medicine
マツオカ, ヒロシ Division of Clinical Otology, University Hospital, The University of Tokushima School of Medicine
テンシン, サトル Department of Orthodontics, The University of Tokushima School of Dentistry
ヤマモト, テルコ Department of Orthodontics, Okayama University Dental School
キーワード
aluminum oxide ceramics
histology
cell count
biocompatible materials
rats
資料タイプ
学術雑誌論文
抄録
The discs of synthetic auditory ossicle (Bioceram®), which are composed of aluminium oxide (Al2O3), were implanted subcutaneously in the interscapular region of 16 rats. The implanted specimens were removed at 1, 3, 7 and 14 days after implantation. The decalcified 6 μm thick sections were stained with H.E. and cell types around the implants were counted microscopically. We found that an acute inflammatory reaction occurred at one day, in which macrophages and neutrophils predominated, and almost disappeared at about 7 days after implantation. Fibrosis began to be observed at 3 days. During this early stage, foreign body giant cells were found in only one specimen at 3 days. These findings, in comparison with those in the controls, showed that the chemical irritation of Bioceram® to the subcutaneous tissue is slight, although the physical and/or chemical irritation of Bioceram® lasts continuously and induces fibrosis around the bioimplant. The results so far suggest that Bioceram® seems to be a satisfactorily biocompatible material, at least within the extent of 2 weeks.
掲載誌名
The journal of medical investigation : JMI
ISSN
13431420
cat書誌ID
AA11166929
44
3-4
開始ページ
173
終了ページ
177
並び順
173
発行日
1998
フルテキストファイル
言語
eng
著者版フラグ
出版社版