ID 110682
Author
Ozawa, Yuichi Department of Pharmacolgy, The University of Tokushima School of Medicine
Hasegawa, Toyoshi Department of Pharmacolgy, The University of Tokushima School of Medicine
Tsuchiya, Koichiro Department of Pharmacolgy, The University of Tokushima School of Medicine Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Yoshizumi, Masanori Department of Pharmacolgy, The University of Tokushima School of Medicine
Tamaki, Toshiaki Department of Pharmacolgy, The University of Tokushima School of Medicine Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Keywords
ET-1(1-31)
ET-1
afferent arteriole
efferent arteriole
Content Type
Journal Article
Description
Human chymase produces not only angiotensin II but also endothelin(ET)-1(1-31). We previously reported that ET-1(1-31) had several biological activities in vascular smooth muscle cells. In this study, we investigated the vasoconstrictor effect of ET-1(1-31) on the renal resistance vessels using in vitro micro perfused rabbit afferent and efferent arterioles.ET-1(1-31) decreased the lumen diameter of the afferent and efferent arterioles dose-dependently.ET-1(1-31)-induced afferent arteriolar vasoconstriction was not affected by phosphoramidon, an ET converting enzyme inhibitor. ET-1(1-31)-induced renal arteriolar vasoconstriction was inhibited by BQ123, an ETA receptor inhibitor, but not by BQ788, an ETB receptor inhibitor. These results suggest that ET-1(1-31)-induced renal arteriolar vasoconstriction may be mediated by ETA-like receptors.
Journal Title
The journal of medical investigation : JMI
ISSN
13431420
NCID
AA11166929
Volume
50
Issue
1-2
Start Page
87
End Page
94
Sort Key
87
Published Date
2003
EDB ID
FullText File
language
eng
TextVersion
Publisher
departments
Pharmaceutical Sciences
Medical Sciences