アクセス数 : ?
ダウンロード数 : ?
ID 110682
著者
小澤, 祐一 Department of Pharmacolgy, The University of Tokushima School of Medicine
長谷川, 豊司 Department of Pharmacolgy, The University of Tokushima School of Medicine
土屋, 浩一郎 Department of Pharmacolgy, The University of Tokushima School of Medicine 徳島大学 教育研究者総覧 KAKEN研究者をさがす
吉栖, 正典 Department of Pharmacolgy, The University of Tokushima School of Medicine
玉置, 俊晃 Department of Pharmacolgy, The University of Tokushima School of Medicine 徳島大学 教育研究者総覧 KAKEN研究者をさがす
キーワード
ET-1(1-31)
ET-1
afferent arteriole
efferent arteriole
資料タイプ
学術雑誌論文
抄録
Human chymase produces not only angiotensin II but also endothelin(ET)-1(1-31). We previously reported that ET-1(1-31) had several biological activities in vascular smooth muscle cells. In this study, we investigated the vasoconstrictor effect of ET-1(1-31) on the renal resistance vessels using in vitro micro perfused rabbit afferent and efferent arterioles.ET-1(1-31) decreased the lumen diameter of the afferent and efferent arterioles dose-dependently.ET-1(1-31)-induced afferent arteriolar vasoconstriction was not affected by phosphoramidon, an ET converting enzyme inhibitor. ET-1(1-31)-induced renal arteriolar vasoconstriction was inhibited by BQ123, an ETA receptor inhibitor, but not by BQ788, an ETB receptor inhibitor. These results suggest that ET-1(1-31)-induced renal arteriolar vasoconstriction may be mediated by ETA-like receptors.
掲載誌名
The journal of medical investigation : JMI
ISSN
13431420
cat書誌ID
AA11166929
50
1-2
開始ページ
87
終了ページ
94
並び順
87
発行日
2003
EDB ID
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
薬学系
医学系