ID 110757
Author
Nagano, Takamasa Division of Psychiatry, Hosogi Unity Hospital
Matsuda, Yukihiko Division of Internal Medicine, Hosogi Unity Hospital
Tanioka, Tetsuya Department of Community and Psychiatric Nursing, School of Medical Sciences, The University of Tokushima Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Yoshioka, Takaoki Division of Psychiatry, Hosogi Unity Hospital
Hiroi, Tadashi Division of Psychiatry, Hosogi Unity Hospital
Yoshikawa, Kenichi Division of Psychiatry, Hosogi Unity Hospital
Okabe, Ken-ichiro Division of Psychiatry, Hosogi Unity Hospital
Osaka, Kyoko Department of Community and Psychiatric Nursing, School of Medical Sciences, The University of Tokushima Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Nagamine, Isao Department of Community and Psychiatric Nursing, School of Medical Sciences, The University of Tokushima
Takasaka, Yoichiro Division of Psychiatry, Hosogi Unity Hospital
Keywords
schizophrenia
β 3-adrenergic receptor polymorphism
obesity
metabolic disease
Trp 64 Arg allele
Content Type
Journal Article
Description
This study was conducted to address the question of whether the β3-adrenergic receptor gene mutation (Trp 64 Arg) is associated with metabolic disease in Japanese patients with schizophrenia. Methods : In a cross-sectional study, 89 participants were grouped into three genotypes. The 64 Arg allelic frequency in patients with or without metabolic disease was analyzed. Anthropometrics variables and biochemical parameters were compared among the genotypes. Results : The 64 Arg allele, which had a frequency of 0.22, was not associated with obesity, type 2 diabetes mellitus, dyslipidemias, or hypertension. No significant differences among the genotypes were found in current age, age at diagnosis with schizophrenia, body mass index, waist-hip ratio, plasma glucose, plasma insulin, triglycerides, free fatty acids. Patients with the 64 Arg allele had greater 24-h excretion of norepinephrine than those lacking the variant (p=0.019). Conclusion : The 64Arg allelic mutation is not associated with obesity, type 2 diabetes mellitus, lipid metabolism dysfunction, or hypertension in Japanese patients with schizophrenia.
Journal Title
The journal of medical investigation : JMI
ISSN
13431420
NCID
AA11166929
Volume
52
Issue
1-2
Start Page
57
End Page
64
Sort Key
57
Published Date
2005-02
EDB ID
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
Publisher
departments
Medical Sciences