直近一年間の累計
アクセス数 : ?
ダウンロード数 : ?
ID 110757
著者
ナガノ, タカマサ Division of Psychiatry, Hosogi Unity Hospital
マツダ, ユキヒコ Division of Internal Medicine, Hosogi Unity Hospital
谷岡, 哲也 Department of Community and Psychiatric Nursing, School of Medical Sciences, The University of Tokushima 徳島大学 教育研究者総覧 KAKEN研究者をさがす
ヨシオカ, タカオキ Division of Psychiatry, Hosogi Unity Hospital
ヒロイ, タダシ Division of Psychiatry, Hosogi Unity Hospital
ヨシカワ, ケンイチ Division of Psychiatry, Hosogi Unity Hospital
オカベ, ケンイチロウ Division of Psychiatry, Hosogi Unity Hospital
大坂, 京子 Department of Community and Psychiatric Nursing, School of Medical Sciences, The University of Tokushima KAKEN研究者をさがす
ナガミネ, イサオ Department of Community and Psychiatric Nursing, School of Medical Sciences, The University of Tokushima
タカサカ, ヨウイチロウ Division of Psychiatry, Hosogi Unity Hospital
キーワード
schizophrenia
β 3-adrenergic receptor polymorphism
obesity
metabolic disease
Trp 64 Arg allele
資料タイプ
学術雑誌論文
抄録
This study was conducted to address the question of whether the β3-adrenergic receptor gene mutation (Trp 64 Arg) is associated with metabolic disease in Japanese patients with schizophrenia. Methods : In a cross-sectional study, 89 participants were grouped into three genotypes. The 64 Arg allelic frequency in patients with or without metabolic disease was analyzed. Anthropometrics variables and biochemical parameters were compared among the genotypes. Results : The 64 Arg allele, which had a frequency of 0.22, was not associated with obesity, type 2 diabetes mellitus, dyslipidemias, or hypertension. No significant differences among the genotypes were found in current age, age at diagnosis with schizophrenia, body mass index, waist-hip ratio, plasma glucose, plasma insulin, triglycerides, free fatty acids. Patients with the 64 Arg allele had greater 24-h excretion of norepinephrine than those lacking the variant (p=0.019). Conclusion : The 64Arg allelic mutation is not associated with obesity, type 2 diabetes mellitus, lipid metabolism dysfunction, or hypertension in Japanese patients with schizophrenia.
掲載誌名
The journal of medical investigation : JMI
ISSN
13431420
cat書誌ID
AA11166929
52
1-2
開始ページ
57
終了ページ
64
並び順
57
発行日
2005-02
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
医学系