ID 110770
Author
Kulwat, Chollada Department of Biochemistry, Chiang Mai University
Lertprasertsuke, Nirush Department of Pathology, Faculty of Medicine, Chiang Mai University
Leechanachai, Pranee Faculty of Associated Medical Science, Chiang Mai University
Kongtawelert, Prachya Department of Biochemistry, Chiang Mai University
Vinitketkumnuen, Usanee Department of Biochemistry, Chiang Mai University
Keywords
antimutagen
DT-diaphorase inducer
Gynostemma pentaphyllum
Content Type
Journal Article
Description
The hotwater extract of the herbal tea, Gynostemma pentaphyllum Makino, was not found tobemutagenicinSalmonellamutationassaywithorwithoutmetabolicactivation.However, the extract had both DT-diaphorase inducing activity in the murine hepatoma (Hepa1c1c7) cell line and antimutagenic properties towards chemical-induced mutation in Salmonella typhimurium strains TA98 and TA100. Mutagenicity of aflatoxinB1(AFB1),2-amino-6-methyldipyrido [1, 2-a : 3’, 2’, 3-d] imidazole (Glu-P-1), 2-aminodipyrido [1, 2-a:3’,2’,3-d]imidazole(Glu-P-2),2-amino- 1, 4-dimethyl-5H-pyrido [4, 3-b] indole (Trp-P-1), 3-amino-1-methyl-5H-pyrido [4, 3-b] indole (Trp-P-2), 2-amino-3-methylimidazo [4, 5-f] quinoline (IQ) and Benzo [a] pyrene (B[a]P)was inhibited by the extract of Gynostemma pentaphyllum Makino in a dose-dependent manner, but no effect was found on the mutagenic activity of 2-(2-Furyl)-3-(5-nitro-2-furyl) acrylamide (AF-2). However, the extract enhanced themutagenicity induced by 2-aminoanthracene (2AA), and N-methyl-N’-nitro-N-nitrosoguanidine (MNNG).
Journal Title
The journal of medical investigation : JMI
ISSN
13431420
NCID
AA11166929
Volume
52
Issue
3-4
Start Page
145
End Page
150
Sort Key
145
Published Date
2005-08
FullText File
language
eng
TextVersion
Publisher