ID 110770
著者
Kulwat, Chollada Department of Biochemistry, Chiang Mai University
Lertprasertsuke, Nirush Department of Pathology, Faculty of Medicine, Chiang Mai University
Leechanachai, Pranee Faculty of Associated Medical Science, Chiang Mai University
Kongtawelert, Prachya Department of Biochemistry, Chiang Mai University
Vinitketkumnuen, Usanee Department of Biochemistry, Chiang Mai University
キーワード
antimutagen
DT-diaphorase inducer
Gynostemma pentaphyllum
資料タイプ
学術雑誌論文
抄録
The hotwater extract of the herbal tea, Gynostemma pentaphyllum Makino, was not found tobemutagenicinSalmonellamutationassaywithorwithoutmetabolicactivation.However, the extract had both DT-diaphorase inducing activity in the murine hepatoma (Hepa1c1c7) cell line and antimutagenic properties towards chemical-induced mutation in Salmonella typhimurium strains TA98 and TA100. Mutagenicity of aflatoxinB1(AFB1),2-amino-6-methyldipyrido [1, 2-a : 3’, 2’, 3-d] imidazole (Glu-P-1), 2-aminodipyrido [1, 2-a:3’,2’,3-d]imidazole(Glu-P-2),2-amino- 1, 4-dimethyl-5H-pyrido [4, 3-b] indole (Trp-P-1), 3-amino-1-methyl-5H-pyrido [4, 3-b] indole (Trp-P-2), 2-amino-3-methylimidazo [4, 5-f] quinoline (IQ) and Benzo [a] pyrene (B[a]P)was inhibited by the extract of Gynostemma pentaphyllum Makino in a dose-dependent manner, but no effect was found on the mutagenic activity of 2-(2-Furyl)-3-(5-nitro-2-furyl) acrylamide (AF-2). However, the extract enhanced themutagenicity induced by 2-aminoanthracene (2AA), and N-methyl-N’-nitro-N-nitrosoguanidine (MNNG).
掲載誌名
The journal of medical investigation : JMI
ISSN
13431420
cat書誌ID
AA11166929
52
3-4
開始ページ
145
終了ページ
150
並び順
145
発行日
2005-08
フルテキストファイル
言語
eng
著者版フラグ
出版社版