ID 110777
Author
Rayhan, Nasim Department of Human Pathology, Institute of Health Biosciences, The University of Tokushima Graduate School
Sano, Toshiaki Department of Human Pathology, Institute of Health Biosciences, The University of Tokushima Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Qian, Zhi Rong Department of Human Pathology, Institute of Health Biosciences, The University of Tokushima Graduate School
Obari, Abdul Kader Department of Human Pathology, Institute of Health Biosciences, The University of Tokushima Graduate School
Hirokawa, Mitsuyoshi Department of Human Pathology, Institute of Health Biosciences, The University of Tokushima Graduate School
Keywords
composite neuroendocrine-exocrine carcinoma
stomach
NCAM
immunohistochemistry
tumorigenesis
Content Type
Journal Article
Description
Composite neuroendocrine-exocrine carcinomas (NEECs) with two distinct components of adenocarcinoma and neuroendocrine (NE)carcinoma within the same tumor are rare but may have a clue for clarifying the pathogenesis of NE tumors arising from non-endocrine organs. This study was done to characterize histological and immunohistochemical features of NEECs of the stomach comparing with pure NE tumors of the gastrointestinal (GI) tract. Microscopically, adenocarcinoma components in 6 of 8 NEECs were well differentiated and located superficially, whereas NE components were poorly differentiated and located deeply. In the remaining two cases, smaller NE components were intermingled within adenocarcinoma components. Immunohistochemically, neural cell adhesion molecule (NCAM) was positive in 5 NE components, of which 3 cases were homogeneously positive, and 2 adenocarcinoma components of 8 NEECs, while 19 of 21 pure NE tumors of GI tract were homogeneously positive for NCAM. Ghrelinimmunoreactivity was found in 4 NE components and 2 adenocarcinoma components of NEECs, although 20 pure NE tumors were positive for ghrelin. Smad4 was positive in both components of 7 NEECs. These findings suggest that composite NEECs and pure NE tumors of GI tract may have different NE properties and that most NE components of composite NEECs of the stomach may originate from an adenocarcinoma precursor cell and occasional tumors from a pluri potent cell.
Journal Title
The journal of medical investigation : JMI
ISSN
13431420
NCID
AA11166929
Volume
52
Issue
3-4
Start Page
191
End Page
202
Sort Key
191
Published Date
2005-08
EDB ID
FullText File
language
eng
TextVersion
Publisher
departments
Medical Sciences