ID 110777
著者
Rayhan, Nasim Department of Human Pathology, Institute of Health Biosciences, The University of Tokushima Graduate School
佐野, 壽昭 Department of Human Pathology, Institute of Health Biosciences, The University of Tokushima Graduate School 徳島大学 教育研究者総覧 KAKEN研究者をさがす
銭, 志栄 Department of Human Pathology, Institute of Health Biosciences, The University of Tokushima Graduate School
Obari, Abdul Kader Department of Human Pathology, Institute of Health Biosciences, The University of Tokushima Graduate School
廣川, 満良 Department of Human Pathology, Institute of Health Biosciences, The University of Tokushima Graduate School
キーワード
composite neuroendocrine-exocrine carcinoma
stomach
NCAM
immunohistochemistry
tumorigenesis
資料タイプ
学術雑誌論文
抄録
Composite neuroendocrine-exocrine carcinomas (NEECs) with two distinct components of adenocarcinoma and neuroendocrine (NE)carcinoma within the same tumor are rare but may have a clue for clarifying the pathogenesis of NE tumors arising from non-endocrine organs. This study was done to characterize histological and immunohistochemical features of NEECs of the stomach comparing with pure NE tumors of the gastrointestinal (GI) tract. Microscopically, adenocarcinoma components in 6 of 8 NEECs were well differentiated and located superficially, whereas NE components were poorly differentiated and located deeply. In the remaining two cases, smaller NE components were intermingled within adenocarcinoma components. Immunohistochemically, neural cell adhesion molecule (NCAM) was positive in 5 NE components, of which 3 cases were homogeneously positive, and 2 adenocarcinoma components of 8 NEECs, while 19 of 21 pure NE tumors of GI tract were homogeneously positive for NCAM. Ghrelinimmunoreactivity was found in 4 NE components and 2 adenocarcinoma components of NEECs, although 20 pure NE tumors were positive for ghrelin. Smad4 was positive in both components of 7 NEECs. These findings suggest that composite NEECs and pure NE tumors of GI tract may have different NE properties and that most NE components of composite NEECs of the stomach may originate from an adenocarcinoma precursor cell and occasional tumors from a pluri potent cell.
掲載誌名
The journal of medical investigation : JMI
ISSN
13431420
cat書誌ID
AA11166929
52
3-4
開始ページ
191
終了ページ
202
並び順
191
発行日
2005-08
EDB ID
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
医学系