ID 110816
Author
Chujo, Keiko Kawashima Hospital
Shima, Kenji Kawashima Hospital
Tada, Hiroaki Kawashima Hospital
Oohashi, Teruyo Kawashima Hospital
Minakuchi, Jun Kawashima Hospital
Kawashima, Syu Kawashima Hospital
Keywords
glycohemoglobin
glycated albumin
hemodialysis
daily profile of blood glucose
life span of erythrocyte
Content Type
Journal Article
Description
Diabetics with end-stage renal disease (ESRD) exhibit abnormal life span of erythrocytes, and thus, HbAlc is not necessarily a good indicator for blood glucose control. The present study was conducted to reaffirm this point and determine whether glycated albumin (GA) can be used instead of HbAlc. The following three groups of patients with diabetes served as subjects : 49 predialysis patients with ESRD (predialysis group), 37 patients with ESRD on dialysis (dialysis group), and 40 patients without nephropathy (non-dialysis group). The profile set mean blood glucose was calculated by measuring blood glucose levels seven times a day. The relationship of profile set mean blood glucose with HbAlc and GA levels was then investigated. Corrected HbAlc levels were calculated by applying the profile set mean blood glucose of each ESRD patient to the regression formula for the HbAlc of non-dialysis patients. The actual and corrected HbAlc levels for the predialysis patients were 5.4±1.1 and 7.9±1.1%, respectively, while those for the dialysis patients were 5.6±1.0 and 7.5±0.9%, respectively (plt0.0001). The changes in GA levels in relation to the blood glucose control in the dialysis patients matched those in non-dialysis patients. HbAlc levels for diabetics with ESRD were lower than indicated by their blood glucose control. When assessing blood glucose control based solely on HbAlc, erroneous results may be obtained. In such cases, GA may be used instead of HbAlc.
Journal Title
The journal of medical investigation : JMI
ISSN
13431420
NCID
AA11166929
Volume
53
Issue
3-4
Start Page
223
End Page
228
Sort Key
223
Published Date
2006-08
FullText File
language
eng
TextVersion
Publisher